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Synonyms: rhC1INH | Ruconest®
conestat alfa is an approved drug (EMA (2010), FDA (2014))
Compound class:
Peptide or derivative
Comment: Conestat alfa is a recombinant analogue of the human C1 esterase inhibitor produced by recombinant DNA technology (in transgenic rabbits). The protein sequence of the enzyme peptide chain is identical to the endogenous human enzyme encoded by the SERPING1 gene (P05155) [1], but it lacks the 22 amino acid signal peptide.
Three nanofiltered/virus filtered, pasteurized, human plasma–derived C1 esterase inhibitor concentrates are already approved by international approval agencies; Berinert® (eMC link), Cetor® (available in the Netherlands and Turkey) and Cinryze® (EMA link). |
Classification  |
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| Compound class | Peptide or derivative |
| Approved drug? | Yes (EMA (2010), FDA (2014)) |
| International Nonproprietary Names |
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| INN number | INN |
| 8899 | conestat alfa |
| Synonyms |
| rhC1INH | Ruconest® |
| Database Links |
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| GtoPdb PubChem SID | 223365962 |
| Search PubMed clinical trials | conestat alfa |
| Search PubMed titles | conestat alfa |
| Search PubMed titles/abstracts | conestat alfa |
