remogliflozin [Ligand Id: 4588] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL494322 (Remogliflozin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3884] [GtoPdb: 916] [UniProtKB: P31639] | ||||||||
| GtoPdb | - | - | 7.9 | pKi | 12.4 | nM | Ki | J Pharmacol Exp Ther (2008) 327: 268-76 [PMID:18583547] |
| ChEMBL | Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption | B | 7.91 | pKi | 12.4 | nM | Ki | J Med Chem (2009) 52: 1785-1794 [PMID:19243175] |
| ChEMBL | Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption | B | 7.85 | pEC50 | 14 | nM | EC50 | J Med Chem (2009) 52: 1785-1794 [PMID:19243175] |
| Sodium/glucose cotransporter 1 in Human [GtoPdb: 915] [UniProtKB: P13866] | ||||||||
| GtoPdb | - | - | 5.3 | pKi | 4520 | nM | Ki | J Pharmacol Exp Ther (2008) 327: 268-76 [PMID:18583547] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
