Synonyms: DS-1001B
Compound class:
Synthetic organic
Comment: The chemical structure for safusidenib was revealed in WHO proposed INN list 126 (Jan 2022), in which it was described as an antineoplastic agent. Chemical SMILES match this structure to the mutant IDH1 inhibitor DS-1001b (Daiichi Sankyo) [1-2], which is a Phase 2 clinical candidate. DS-1001b is orally bioavaliable and is able to cross the blood-brain-barrier.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(E)-3-[1-[5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazole-4-carbonyl]-3-methylindol-4-yl]prop-2-enoic acid |
International Nonproprietary Names ![]() |
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INN number | INN |
11941 | safusidenib |
Synonyms ![]() |
DS-1001B |
Database Links ![]() |
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CAS Registry No. | 1898206-17-1 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL4651002 |
GtoPdb PubChem SID | 461663440 |
PubChem CID | 130306983 |
RCSB PDB Ligand | 7SU, 7SU |
Search Google for chemical match using the InChIKey | BOOMBLZEOHXPPX-BQYQJAHWSA-N |
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Search PubMed clinical trials | safusidenib |
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UniChem Compound Search for chemical match using the InChIKey | BOOMBLZEOHXPPX-BQYQJAHWSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | BOOMBLZEOHXPPX-BQYQJAHWSA-N |