ChEMBL ligand: CHEMBL70 (Anhydrous morphine, Avinza, Depodur, Hydromorphone hydrochloride impurity, morphine-, IDS-NM-009, Infumorph, Kadian, Morphia, Morphine, Morphine anhydrous, Morphine (anhydrous), Morphine extended release, Morphine polistirex, Morphium, N02AA01, Nepenthe, Ospalivina)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Mouse [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] Mu opioid receptor in Bovine [ChEMBL: CHEMBL3041] [UniProtKB: P79350] μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!
α2A-adrenoceptor/μ receptor/Mu opioid receptor/Alpha-2A adrenergic receptor in Human [ChEMBL: CHEMBL3883321] [GtoPdb: 25, 319] [UniProtKB: P08913, P35372] α2A-adrenoceptor/μ receptor in Rat [GtoPdb: 25, 319] [UniProtKB: P22909, P33535] There should be some charts here, you may need to enable JavaScript!
Mu opioid receptor-like OR2 in Danio rerio [ChEMBL: CHEMBL3611961] [UniProtKB: Q98UH1] There should be some charts here, you may need to enable JavaScript!
Nociceptin receptor in Guinea pig [ChEMBL: CHEMBL5492] [UniProtKB: P47748] There should be some charts here, you may need to enable JavaScript!
Opioid receptor, delta 1b in Danio rerio [ChEMBL: CHEMBL4105711] [UniProtKB: B3DH72] There should be some charts here, you may need to enable JavaScript!
Opioid receptor homologue in Danio rerio [ChEMBL: CHEMBL4105897] [UniProtKB: O57585] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] P-glycoprotein 1 in Mouse [ChEMBL: CHEMBL3467] [UniProtKB: P06795] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 3 in Mouse [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Binding affinity against Opioid receptor delta 1 in guinea pig brain membranes	B	6.15	pKi	710	nM	Ki	Bioorg Med Chem Lett (1998) 8: 2685-2688 [PMID:9873603]
ChEMBL	Binding affinities against Opioid receptor delta 1 of guinea pig brain membrane using [3H]DPDPE as the radioligand using competition binding assays.	B	6.2	pKi	629.51	nM	Ki	J Med Chem (1990) 33: 206-212 [PMID:1967312]
ChEMBL	Displacement of [3H]DADLE from human recombinant opioid delta receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	B	6.22	pKi	605	nM	Ki	Eur J Med Chem (2015) 92: 531-539 [PMID:25599950]
ChEMBL	Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis	B	6.22	pKi	605	nM	Ki	Bioorg Med Chem (2013) 21: 3298-3309 [PMID:23618710]
ChEMBL	Displacement of [3H]-DADLE from human delta opioid receptor expressed in CHO cells membrane after 2 hrs by liquid scintillation counting	B	6.22	pKi	605	nM	Ki	Eur J Med Chem (2012) 50: 44-54 [PMID:22341895]
ChEMBL	Displacement of [3H]DADLE from human delta opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting	B	6.22	pKi	605	nM	Ki	Eur J Med Chem (2013) 67: 335-343 [PMID:23880358]
ChEMBL	Binding affinity against Opioid receptor delta 1 was determined in brain membrane preparations from male Hartley guinea-pigs	B	6.29	pKi	510	nM	Ki	Bioorg Med Chem Lett (1998) 8: 1813-1818 [PMID:9873439]
ChEMBL	Compound was evaluated for its binding affinity against opioid receptor delta subtype in guinea pig brain (minus cerebellum) using [3H]-DADLE as radioligand.	B	6.34	pKi	460	nM	Ki	J Med Chem (1991) 34: 397-403 [PMID:1846921]
ChEMBL	Affinity for opioid receptor delta sites	B	6.34	pKi	456	nM	Ki	J Med Chem (1991) 34: 2624-2633 [PMID:1652025]
ChEMBL	Receptor binding affinity towards opioid receptor delta	B	6.34	pKi	456	nM	Ki	J Med Chem (1992) 35: 2970-2978 [PMID:1323679]
ChEMBL	Binding affinity of compound was determined against Opioid receptor delta 1 from a native receptor in guinea pig	B	6.34	pKi	456	nM	Ki	J Med Chem (2003) 46: 3853-3864 [PMID:12930147]
ChEMBL	Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor delta 1 using [3H]DPDPE as radioligand	B	6.38	pKi	416.87	nM	Ki	J Med Chem (2002) 45: 1949-1956 [PMID:11960505]
ChEMBL	In vivo binding affinity against delta Opioid receptor was measured by using labeled ligand [3H]DADLE (1 nM) with 4 nM sufentanil	B	6.43	pKi	375	nM	Ki	J Med Chem (1994) 37: 3121-3127 [PMID:7932535]
ChEMBL	Displacement of [3H]diprenorphine from human DOR expressed in African green monkey COS1 cell membranes incubated for 1 hr by scintillation counting method	B	6.47	pKi	340	nM	Ki	Eur J Med Chem (2018) 151: 495-507 [PMID:29649744]
ChEMBL	Binding affinity determined against Opioid receptor delta 1 from human cloned receptor	B	6.52	pKi	299	nM	Ki	J Med Chem (2003) 46: 3853-3864 [PMID:12930147]
ChEMBL	Displacement of [3H]DPDPE from delta-opioid receptor expressed in CHOK1 cells after overnight incubation by scintillation proximity assay	B	6.53	pKi	295	nM	Ki	J Med Chem (2012) 55: 5859-5867 [PMID:22680612]
ChEMBL	Binding affinity towards Opioid receptor delta 1	B	6.55	pKi	280	nM	Ki	J Med Chem (1992) 35: 1521-1525 [PMID:1315868]
ChEMBL	In vitro potency was measured against human Opioid receptor delta 1	B	6.82	pKi	150	nM	Ki	J Med Chem (1998) 41: 2631-2635 [PMID:9651168]
ChEMBL	Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor delta 1 expressed in CHO cell membrane;Range is between (63-360)	B	6.82	pKi	150	nM	Ki	J Med Chem (2002) 45: 3746-3754 [PMID:12166947]
ChEMBL	Binding affinity towards Opioid receptor delta 1 of guinea pig brain membranes using radioligand 0.2 nM [3H]Naltrindole	B	6.85	pKi	140	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1717-1721 [PMID:11425545]
ChEMBL	Inhibition of [3H]naltrindole binding to opioid receptor delta 1 of Chinese hamster ovary membrane	B	6.85	pKi	140	nM	Ki	J Med Chem (2004) 47: 1886-1888 [PMID:15055988]
ChEMBL	Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.	B	6.85	pKi	140	nM	Ki	J Med Chem (2000) 43: 3558-3565 [PMID:11000010]
ChEMBL	Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells	B	6.85	pKi	140	nM	Ki	J Med Chem (2006) 49: 256-262 [PMID:16392810]
ChEMBL	Displacement of [3H]Cl-DPDPE from human recombinant DOR expressed in CHO cells	B	6.85	pKi	140	nM	Ki	J Med Chem (2006) 49: 5333-5338 [PMID:16913723]
ChEMBL	Displacement of [3H]DPDPE from human cloned delta opioid receptor	B	6.85	pKi	140	nM	Ki	J Med Chem (2007) 50: 5176-5182 [PMID:17887741]
ChEMBL	Displacement of [3H]-naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting	B	6.85	pKi	140	nM	Ki	J Med Chem (2012) 55: 3878-3890 [PMID:22439881]
ChEMBL	Activity was evaluated by inhibition of the binding of 1 nM [3H]DPDPE at Opioid receptor delta 1 binding site	B	6.88	pKi	132	nM	Ki	J Med Chem (1996) 39: 1956-1966 [PMID:8642554]
GtoPdb	-	-	6.9	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Binding affinity for Opioid receptor delta 1 was determined	B	6.95	pKi	113.3	nM	Ki	Bioorg Med Chem Lett (2002) 12: 3141-3143 [PMID:12372519]
ChEMBL	Displacement of [3H]diprenorphine from recombinant delta opioid receptor expressed in C6 cells	B	6.98	pKi	104.57	nM	Ki	J Med Chem (2008) 51: 2316-2320 [PMID:18311899]
ChEMBL	Displacement of [3H]diprenorphine from human DOR expressed in CHO cell membranes incubated for 1 hr by liquid scintillation counting assay	B	6.98	pKi	104.1	nM	Ki	J Med Chem (2020) 63: 1671-1683 [PMID:31986033]
ChEMBL	Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brain	B	7.24	pKi	58	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4291-4295 [PMID:16777416]
ChEMBL	Compound was evaluated for the binding affinity to delta opioid receptor	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (1992) 2: 715-720
ChEMBL	Binding to delta opioid receptor by using [3H]DPDPE as radioligand in guinea pig brain minus cerebellum	B	6.37	pIC50	430	nM	IC50	Bioorg Med Chem Lett (1994) 4: 2527-2532
ChEMBL	Evaluated for the inhibition of [3H]DADLE binding to Opioid receptor delta 1 of guinea pig brain	B	6.73	pIC50	185	nM	IC50	J Med Chem (1987) 30: 1538-1542 [PMID:2887656]
ChEMBL	In vitro binding affinity against cloned human Opioid receptor delta 1 expressed in HEK 293S cells	B	6.82	pIC50	150	nM	IC50	J Med Chem (2003) 46: 34-48 [PMID:12502358]
ChEMBL	Agonist activity at human delta opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 mins by HitHunter luminescence based assay	F	6.11	pEC50	780	nM	EC50	J Med Chem (2016) 59: 11027-11038 [PMID:27958743]
ChEMBL	Agonist activity at human DOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scintillation counting assay	F	6.23	pEC50	>593	nM	EC50	J Med Chem (2020) 63: 1671-1683 [PMID:31986033]
ChEMBL	Agonist activity at human DOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assay	F	6.3	pEC50	500	nM	EC50	Bioorg Med Chem Lett (2013) 23: 4870-4874 [PMID:23880538]
ChEMBL	Stimulation of [35S]GTP-gamma-S binding to human recombinant DOR	F	6.5	pEC50	316	nM	EC50	J Med Chem (2006) 49: 5333-5338 [PMID:16913723]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	F	6.5	pEC50	316	nM	EC50	J Med Chem (2009) 52: 1553-1557 [PMID:19253983]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins	F	7.81	pEC50	15.6	nM	EC50	J Med Chem (2011) 54: 980-988 [PMID:21235243]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	In vitro agonistic activity against opioid receptor delta of mouse vas deferens	F	5.8	pIC50	1600	nM	IC50	J Med Chem (2005) 48: 3372-3378 [PMID:15857143]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellum	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6398-6401 [PMID:18990576]
ChEMBL	Evaluated for inhibitory activity against Opioid receptor delta 1 of mouse vas deferens (MVD).	B	6.13	pIC50	736	nM	IC50	J Med Chem (1990) 33: 206-212 [PMID:1967312]
ChEMBL	Ability to inhibit electrically evoked contractions of isolated muscle preparations of mouse vas deference (MVD, delta receptor)	F	6.19	pIC50	644	nM	IC50	J Med Chem (2002) 45: 3746-3754 [PMID:12166947]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in ICR mouse whole brain	B	6.3	pIC50	<500	nM	IC50	Bioorg Med Chem (2008) 16: 4304-4312 [PMID:18337104]
ChEMBL	Inhibitory potency against delta Opioid receptor delta 1 in longitudinal muscle preparation of mouse vas deferens	B	6.41	pIC50	390	nM	IC50	J Med Chem (1981) 24: 1119-1124 [PMID:6276540]
ChEMBL	Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction	B	6.81	pIC50	155	nM	IC50	Bioorg Med Chem (2014) 22: 4581-4586 [PMID:25129170]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Displacement of [3H][Ile5,6]deltorphin2 from delta opioid receptor in rat brain membrane	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2010) 18: 5071-5080 [PMID:20580236]
ChEMBL	Binding affinity towards Opioid receptor delta 1 using [3H]DADLE as radioligand.	B	6.16	pKi	684	nM	Ki	J Med Chem (1995) 38: 1547-1557 [PMID:7739013]
ChEMBL	Inhibition of [3H]DSLET binding to delta 1 opioid receptors in rat brain membranes	B	6.55	pKi	280	nM	Ki	J Med Chem (1988) 31: 374-383 [PMID:2828622]
ChEMBL	In vitro binding affinity at opioid receptor delta 1 was determined in C6 rat glioma cells using [3H]Ile5,6 deltorphin II	B	6.66	pKi	217	nM	Ki	J Med Chem (2003) 46: 1758-1763 [PMID:12699394]
ChEMBL	Inhibition of [3H][Ile5,6]deltorphin II binding to opioid receptor delta from rat brain membranes	B	6.66	pKi	217	nM	Ki	J Med Chem (2005) 48: 3372-3378 [PMID:15857143]
ChEMBL	Binding affinity against Opioid receptor delta 1 isolated from rat brain membrane was determined using [3H][Ile]-deltorphin as radioligand	B	6.66	pKi	217	nM	Ki	J Med Chem (2003) 46: 4182-4187 [PMID:12954070]
ChEMBL	Displacement of [3H[Ile5,6]-deltorphin II from delta opioid receptor of rat brain membranes	B	6.66	pKi	217	nM	Ki	J Med Chem (2005) 48: 5052-5055 [PMID:16033285]
ChEMBL	Displacement of [3H]-diprenorphine from rat delta-type opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by liquid scintillation counting method	B	6.77	pKi	171	nM	Ki	J Med Chem (2019) 62: 4142-4157 [PMID:30924650]
ChEMBL	Displacement of [3H]diprenorphine from rat DOR expressed in rat C6 cells after 1 hr by liquid scintillation counting analysis	B	6.77	pKi	171	nM	Ki	J Med Chem (2013) 56: 2139-2149 [PMID:23419026]
ChEMBL	Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membrane	B	6.8	pKi	157	nM	Ki	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	Displacement of [3H]DPDPE from rat delta opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting method	B	6.93	pKi	116.8	nM	Ki	J Med Chem (2021) 64: 12414-12433 [PMID:34387468]
ChEMBL	Displacement of [3H][Ile5,6]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain membrane by liquid scintillation counting	B	6.95	pKi	113	nM	Ki	J Med Chem (2011) 54: 980-988 [PMID:21235243]
ChEMBL	Inhibition of [3H]DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes	B	7.05	pKi	90	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1109-1111 [PMID:10843229]
ChEMBL	Inhibition of binding of [3H]-DPDPE to opioid receptor delta 1 from rat brain membrane.	B	7.05	pKi	90	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1741-1743 [PMID:11425550]
ChEMBL	Binding affinity of compound evaluated for Opioid receptor delta 1 isolated from rat brain	B	7.05	pKi	90	nM	Ki	J Med Chem (2003) 46: 623-633 [PMID:12570383]
ChEMBL	Displacement of [3H]DSLET from delta opioid receptor in rat brain membranes	B	7.08	pKi	82.5	nM	Ki	Bioorg Med Chem (2014) 22: 4581-4586 [PMID:25129170]
ChEMBL	Displacement of [3H]diprenorphine from rat delta receptor expressed in CHO cells by scintillation counting	B	7.11	pKi	76.9	nM	Ki	Bioorg Med Chem Lett (2010) 20: 418-421 [PMID:19932964]
ChEMBL	Inhibition of [3H]-[D-Pen2, D-Pen5]-enkephalin (2 nM) to Opioid receptor delta 1 of male Sprague-Dawley rat brain homogenate	B	7.82	pKi	15	nM	Ki	Bioorg Med Chem Lett (1995) 5: 589-592
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in Sprague-Dawley rat brain membranes after 120 mins by scintillation counting analysis	B	8.7	pKi	2	nM	Ki	Medchemcomm (2016) 7: 2368-2380
ChEMBL	Displacement of [3H]-DPDPE from delta opioid receptor in rat brain membrane after 120 mins by scintillation counting	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5326-5330 [PMID:26411794]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in rat membranes after 120 mins by scintillation counting analysis	B	8.7	pKi	2	nM	Ki	J Med Chem (2019) 62: 4204-4217 [PMID:30939014]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in rat brain membranes	B	8.74	pKi	1.8	nM	Ki	Eur J Med Chem (2011) 46: 1972-1982 [PMID:21481987]
ChEMBL	Inhibition of [3H]- DADLE binding to Rat brain Opioid receptor delta 1	B	6.16	pIC50	684	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
ChEMBL	Inhibition of [3H]DADLE radioligand binding to rat brain opioid receptor delta 1.	B	6.16	pIC50	684	nM	IC50	J Med Chem (1995) 38: 1523-1537 [PMID:7739011]
ChEMBL	Displacement of [3H]deltorphin-2 from delta opioid receptor from Wistar rat brain by liquid scintillation counting	B	6.39	pIC50	404	nM	IC50	Bioorg Med Chem (2010) 18: 3535-3542 [PMID:20413312]
ChEMBL	Displacement of [3H]DSLET from delta opioid receptor in rat brain membrane	B	6.69	pIC50	205	nM	IC50	J Med Chem (1991) 34: 1656-1661 [PMID:1851843]
ChEMBL	Inhibition of [3H]DADLE radioligand binding to rat brain opioid receptor delta 1.	B	8.13	pIC50	7.37	nM	IC50	J Med Chem (1995) 38: 1523-1537 [PMID:7739011]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Compound was evaluated for the binding affinity to kappa opioid receptor	B	5.72	pKi	1900	nM	Ki	Bioorg Med Chem Lett (1992) 2: 715-720
ChEMBL	Displacement of [3H]-U69593 from human kappa opioid receptor expressed in CHO cells membrane after 2 hrs by liquid scintillation counting	B	6.52	pKi	299	nM	Ki	Eur J Med Chem (2012) 50: 44-54 [PMID:22341895]
ChEMBL	Displacement of [3H]U69,593 from human recombinant opioid kappa receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	B	6.52	pKi	299	nM	Ki	Eur J Med Chem (2015) 92: 531-539 [PMID:25599950]
ChEMBL	Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting	B	6.52	pKi	299	nM	Ki	Eur J Med Chem (2013) 67: 335-343 [PMID:23880358]
ChEMBL	Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis	B	6.52	pKi	299	nM	Ki	Bioorg Med Chem (2013) 21: 3298-3309 [PMID:23618710]
ChEMBL	In vitro potency was measured against human Opioid receptor kappa 1	B	6.59	pKi	260	nM	Ki	J Med Chem (1998) 41: 2631-2635 [PMID:9651168]
ChEMBL	Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor kappa 1 expressed in CHO cell membrane	B	6.59	pKi	260	nM	Ki	J Med Chem (2002) 45: 3746-3754 [PMID:12166947]
ChEMBL	Binding affinity to human kappa opioid receptor	B	6.92	pKi	120	nM	Ki	J Med Chem (2016) 59: 810-840 [PMID:26390077]
ChEMBL	In vitro binding affinity at opioid receptor kappa 1 was determined in human CHO cells using [3H]U-69593	B	6.95	pKi	113	nM	Ki	J Med Chem (2003) 46: 1758-1763 [PMID:12699394]
ChEMBL	Binding affinity towards Opioid receptor kappa 1 was determined	B	7.07	pKi	86	nM	Ki	J Med Chem (1989) 32: 1620-1626 [PMID:2567782]
ChEMBL	Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting method	B	7.11	pKi	76.9	nM	Ki	J Med Chem (2021) 64: 12414-12433 [PMID:34387468]
ChEMBL	Displacement of [3H]diprenorphine from recombinant kappa opioid receptor expressed in CHO cells	B	7.18	pKi	65.5	nM	Ki	J Med Chem (2008) 51: 2316-2320 [PMID:18311899]
ChEMBL	Binding affinity against opioid receptor kappa 1 from human cloned receptor	B	7.19	pKi	64	nM	Ki	J Med Chem (2003) 46: 3853-3864 [PMID:12930147]
ChEMBL	Displacement of [3H]-diprenorphine from human kappa-type opioid receptor expressed in CHO cell membranes incubated for 1 hr by liquid scintillation counting method	B	7.21	pKi	61	nM	Ki	J Med Chem (2019) 62: 4142-4157 [PMID:30924650]
ChEMBL	Displacement of [3H]diprenorphine from human KOR expressed in CHO cells after 1 hr by liquid scintillation counting analysis	B	7.22	pKi	60.9	nM	Ki	J Med Chem (2013) 56: 2139-2149 [PMID:23419026]
ChEMBL	Binding affinity for Opioid receptor kappa 1 was determined.	B	7.28	pKi	52.14	nM	Ki	Bioorg Med Chem Lett (2002) 12: 3141-3143 [PMID:12372519]
GtoPdb	-	-	7.3	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Displacement of [3H]U-69593 from human cloned kappa opioid receptor	B	7.33	pKi	46.9	nM	Ki	J Med Chem (2007) 50: 5176-5182 [PMID:17887741]
ChEMBL	Displacement of [3H]U-69593 from human recombinant KOR expressed in CHO cells	B	7.33	pKi	46.9	nM	Ki	J Med Chem (2006) 49: 5333-5338 [PMID:16913723]
ChEMBL	Displacement of [3H]diprenorphine from human KOR expressed in CHO cell membranes incubated for 1 hr by liquid scintillation counting assay	B	7.43	pKi	36.8	nM	Ki	J Med Chem (2020) 63: 1671-1683 [PMID:31986033]
ChEMBL	Binding affinity to kappa opioid receptor	B	7.47	pKi	33.7	nM	Ki	Bioorg Med Chem (2010) 18: 4446-4452 [PMID:20478711]
ChEMBL	Binding affinity towards opioid receptor kappa 2	B	7.48	pKi	33	nM	Ki	J Med Chem (1992) 35: 1521-1525 [PMID:1315868]
ChEMBL	Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of Chinese hamster ovary membrane	B	7.62	pKi	24	nM	Ki	J Med Chem (2004) 47: 1886-1888 [PMID:15055988]
ChEMBL	Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting	B	7.62	pKi	24	nM	Ki	J Med Chem (2012) 55: 3878-3890 [PMID:22439881]
ChEMBL	Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells	B	7.62	pKi	24	nM	Ki	J Med Chem (2006) 49: 256-262 [PMID:16392810]
ChEMBL	Displacement of [3H]diprenorphine from kappa-opioid receptor expressed in CHOK1 cells after overnight incubation by scintillation proximity assay	B	7.88	pKi	13.3	nM	Ki	J Med Chem (2012) 55: 5859-5867 [PMID:22680612]
ChEMBL	Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation counting	B	8.16	pKi	6.9	nM	Ki	Bioorg Med Chem Lett (2010) 20: 418-421 [PMID:19932964]
ChEMBL	In vitro binding affinity against cloned human Opioid receptor kappa 1 expressed in HEK 293S cells	B	5.77	pIC50	1705.1	nM	IC50	J Med Chem (2003) 46: 34-48 [PMID:12502358]
ChEMBL	Stimulation of [35S]GTP-gamma-S binding to human recombinant KOR	F	6.32	pEC50	484	nM	EC50	J Med Chem (2006) 49: 5333-5338 [PMID:16913723]
ChEMBL	Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding	F	6.32	pEC50	484	nM	EC50	J Med Chem (2007) 50: 5176-5182 [PMID:17887741]
ChEMBL	Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding