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Target not currently curated in GtoImmuPdb
Target id: 768
Nomenclature: ABCB1
Abbreviated Name: MDR1, PGP1
Systematic Nomenclature: ABCB1
Family: ABCB subfamily
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 12 | 1280 | 7q21.12 | ABCB1 | ATP binding cassette subfamily B member 1 | |
Mouse | 12 | 1276 | 5 3.43 cM | Abcb1a | ATP-binding cassette, sub-family B (MDR/TAP), member 1A | |
Rat | - | - | Abcb1a | ATP binding cassette subfamily B member 1A |
Database Links ![]() |
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ChEMBL Target | CHEMBL4302 (Hs), CHEMBL2573 (Mm) |
DrugBank Target | P08183 (Hs) |
Ensembl Gene | ENSG00000085563 (Hs), ENSMUSG00000040584 (Mm), ENSRNOG00000008012 (Rn) |
Entrez Gene | 5243 (Hs), 18671 (Mm), 170913 (Rn) |
Human Protein Atlas | ENSG00000085563 (Hs) |
KEGG Gene | hsa:5243 (Hs), mmu:18671 (Mm), rno:170913 (Rn) |
OMIM | 171050 (Hs) |
Pharos | P08183 (Hs) |
UniProtKB | P08183 (Hs), P21447 (Mm) |
Wikipedia | ABCB1 (Hs) |
Selected 3D Structures ![]() |
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||
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Biologically Significant Variant Comments |
Nonsense mutation in ABCB1 has been described in collie dogs [3-4] and when these animals are treated with ivermectin they develop potentially fatal neurologic disorders, due to a toxic accumulation of ivermectin in the central nervous system. Similar ivermectin-induced pathology has been noted in humans. In 2020 mutated human ABCB1 alleles were identified in a patient who developed serious ivermectin toxicity following a single oral dose of the drug. Genetic analysis revealed that this patient harboured a different nonsense alteration in each copy of their ABCB1 genes. Both mutations generated premature stop codons and truncated transporter proteins that lacked the C-terminal nucleotide-binding domain, rendering the proteins incapable of drug-transport [1]. |
1. Baudou E, Lespine A, Durrieu G, André F, Gandia P, Durand C, Cunat S. (2020) Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations. N Engl J Med, 383: 787-789 [Epub ahead of print]. DOI: 10.1056/NEJMc1917344
2. Kim Y, Chen J. (2018) Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. Science, 359 (6378): 915-919. [PMID:29371429]
3. Mealey KL. (2004) Therapeutic implications of the MDR-1 gene. J Vet Pharmacol Ther, 27 (5): 257-64. [PMID:15500562]
4. Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP et al.. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell, 77 (4): 491-502. [PMID:7910522]
5. Silbermann K, Stefan SM, Elshawadfy R, Namasivayam V, Wiese M. (2019) Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach. J Med Chem, 62 (9): 4383-4400. [PMID:30925062]