Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	-		ABCB1	ATP binding cassette subfamily B member 1
Mouse	-	-		Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Rat	-	-		Abcb1a	ATP binding cassette subfamily B member 1A

Previous and Unofficial Names

P-glycoprotein 1 | ABC20 | CD243 | CLCS | GP170 | MDR1 | PGY1 | colchicin sensitivity | multidrug resistance protein 1 | Abcb1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | ATP-binding cassette, subfamily B (MDR/TAP), member 1A | Mdr1a | multiple drug resistant 1a | Evi32 | MDR3 | mdr-3 | Pgp | Pgy3 | Pgy-3 | P-gp | Abcb1a | ATP binding cassette subfamily B member 1 | ATP-binding cassette

Database Links
ChEMBL Target	CHEMBL4302 (Hs), CHEMBL2573 (Mm)
DrugBank Target	P08183 (Hs)
Ensembl Gene	ENSG00000085563 (Hs), ENSMUSG00000040584 (Mm), ENSRNOG00000008012 (Rn)
Entrez Gene	5243 (Hs), 18671 (Mm), 170913 (Rn)
Human Protein Atlas	ENSG00000085563 (Hs)
KEGG Gene	hsa:5243 (Hs), mmu:18671 (Mm), rno:170913 (Rn)
OMIM	171050 (Hs)
UniProtKB	P08183 (Hs), P21447 (Mm)
Wikipedia	ABCB1 (Hs)

Selected 3D Structures
	Description:  Molecular structure of human P-glycoprotein (ABCB1) in the ATP-bound, outward-facing conformation PDB Id:  6C0V Ligand:  ATP    Resolution:  3.4Å Species:  Human References:  1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 14 [PMID: 30925062] Hs Competitive 5.8 – 6.2 pIC50 2 ⤷ pIC50 6.2 (IC50 6.76x10-7 M) [2] Description: Measuring inhibition of cyclosporine A transport in A2780/ADR cells expressing hABCB1. pIC50 5.8 (IC50 1.73x10-6 M) [2] Description: Measuring inhibition of calcein AM transport in A2780/ADR cells expressing hABCB1.