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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [1,5].
MDR1, PGP1 (ABCB1) C Show summary »« Hide summary More detailed page
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TAP1 (ABCB2) C Show summary »« Hide summary
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TAP2 (ABCB3) C Show summary »« Hide summary More detailed page
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PGY3 (ABCB4) C Show summary »« Hide summary
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ABCB5 C Show summary »« Hide summary
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MTABC3 (ABCB6) C Show summary »« Hide summary
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ABC7 (ABCB7) C Show summary »« Hide summary
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MABC1 (ABCB8) C Show summary »« Hide summary
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TAPL (ABCB9) C Show summary »« Hide summary
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MTABC2 (ABCB10) C Show summary »« Hide summary
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ABC16 (ABCB11) C Show summary »« Hide summary
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1. Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al.. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol, 176 Suppl 1: S397-S493. [PMID:31710713]
2. Bayeva M, Khechaduri A, Wu R, Burke MA, Wasserstrom JA, Singh N, Liesa M, Shirihai OS, Langer NB, Paw BH et al.. (2013) ATP-binding cassette B10 regulates early steps of heme synthesis. Circ Res, 113 (3): 279-87. [PMID:23720443]
3. Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ. (2002) The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology, 123 (5): 1649-58. [PMID:12404239]
4. Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, Kumer S, Gunewardena S, Gaikwad N, Krishnamurthy P. (2015) Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver. J Biol Chem, 290 (12): 7871-86. [PMID:25623066]
5. Dean M, Hamon Y, Chimini G. (2001) The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res, 42 (7): 1007-17. [PMID:11441126]
6. Demirel Ö, Jan I, Wolters D, Blanz J, Saftig P, Tampé R, Abele R. (2012) The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2. J Cell Sci, 125 (Pt 18): 4230-40. [PMID:22641697]
7. Elliott AM, Al-Hajj MA. (2009) ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Mol Cancer Res, 7 (1): 79-87. [PMID:19147539]
8. Garzel B, Yang H, Zhang L, Huang SM, Polli JE, Wang H. (2014) The role of bile salt export pump gene repression in drug-induced cholestatic liver toxicity. Drug Metab Dispos, 42 (3): 318-22. [PMID:24335466]
9. Helias V, Saison C, Ballif BA, Peyrard T, Takahashi J, Takahashi H, Tanaka M, Deybach JC, Puy H, Le Gall M et al.. (2012) ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis. Nat Genet, 44 (2): 170-3. [PMID:22246506]
10. Hirschfield GM, Chapman RW, Karlsen TH, Lammert F, Lazaridis KN, Mason AL. (2013) The genetics of complex cholestatic disorders. Gastroenterology, 144 (7): 1357-74. [PMID:23583734]
11. Ichikawa Y, Bayeva M, Ghanefar M, Potini V, Sun L, Mutharasan RK, Wu R, Khechaduri A, Jairaj Naik T, Ardehali H. (2012) Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. Proc Natl Acad Sci USA, 109 (11): 4152-7. [PMID:22375032]
12. Krishnamurthy PC, Du G, Fukuda Y, Sun D, Sampath J, Mercer KE, Wang J, Sosa-Pineda B, Murti KG, Schuetz JD. (2006) Identification of a mammalian mitochondrial porphyrin transporter. Nature, 443 (7111): 586-9. [PMID:17006453]
13. Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL et al.. (2014) ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature, 511 (7509): 353-7. [PMID:25030174]
14. Morgan RE, Trauner M, van Staden CJ, Lee PH, Ramachandran B, Eschenberg M, Afshari CA, Qualls Jr CW, Lightfoot-Dunn R, Hamadeh HK. (2010) Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci, 118 (2): 485-500. [PMID:20829430]
15. Oude Elferink RP, Paulusma CC. (2007) Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). Pflugers Arch, 453 (5): 601-10. [PMID:16622704]
16. Pondarre C, Campagna DR, Antiochos B, Sikorski L, Mulhern H, Fleming MD. (2007) Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood, 109 (8): 3567-9. [PMID:17192398]
17. Pondarré C, Antiochos BB, Campagna DR, Clarke SL, Greer EL, Deck KM, McDonald A, Han AP, Medlock A, Kutok JL et al.. (2006) The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet, 15 (6): 953-64. [PMID:16467350]
18. Seyffer F, Tampé R. (2015) ABC transporters in adaptive immunity. Biochim Biophys Acta, 1850 (3): 449-60. [PMID:24923865]
19. Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J et al.. (2013) Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc Natl Acad Sci USA, 110 (24): 9710-5. [PMID:23716676]
20. Stieger B. (2009) Recent insights into the function and regulation of the bile salt export pump (ABCB11). Curr Opin Lipidol, 20 (3): 176-81. [PMID:19684528]
21. Tang L, Bergevoet SM, Bakker-Verweij G, Harteveld CL, Giordano PC, Nijtmans L, de Witte T, Jansen JH, Raymakers RA, van der Reijden BA. (2012) Human mitochondrial ATP-binding cassette transporter ABCB10 is required for efficient red blood cell development. Br J Haematol, 157 (1): 151-4. [PMID:22085049]
22. Wilson BJ, Saab KR, Ma J, Schatton T, Pütz P, Zhan Q, Murphy GF, Gasser M, Waaga-Gasser AM, Frank NY et al.. (2014) ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Cancer Res, 74 (15): 4196-207. [PMID:24934811]
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.
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