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ABCB3

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 770

Nomenclature: ABCB3

Abbreviated Name: TAP2

Systematic Nomenclature: ABCB3

Family: ABCB subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 9 686 6p21.32 TAP2 transporter 2, ATP binding cassette subfamily B member
Mouse 9 702 17 17.98 cM Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Rat 9 703 20p12 Tap2 transporter 2, ATP binding cassette subfamily B member
Previous and Unofficial Names Click here for help
Antigen peptide transporter 2 (APT2) | peptide supply factor 2 (PSF-2) | Peptide transporter TAP2 | ATP-binding cassette sub-family B member 3 | Cim | Transporter 2 ABC (ATP binding cassette) | Ham2 | MTP2 | peptide transporter involved in antigen processing 2 | RING11 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | transporter 2 | transporter 2, ATP binding cassette subfamily B member
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
TAP1 (ABCB2) and TAP2 (ABCB3) form a transporter that plays an important role in antigen presentation by major histocompatibility complex class I (MHCI) molecules in the adaptive immune response [1].
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 8 GO processes
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent IMP
GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I ISO
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IDA
GO:0046968 peptide antigen transport IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA
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GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA
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GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA
GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I ISO
GO:0042270 protection from natural killer cell mediated cytotoxicity ISO
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0042270 protection from natural killer cell mediated cytotoxicity ISO

References

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1. Seyffer F, Tampé R. (2015) ABC transporters in adaptive immunity. Biochim Biophys Acta, 1850 (3): 449-60. [PMID:24923865]

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