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NOP receptor

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Target not currently curated in GtoImmuPdb

Target id: 320

Nomenclature: NOP receptor

Family: Opioid receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 370 20q13.33 OPRL1 opioid related nociceptin receptor 1 66
Mouse 7 367 2 103.74 cM Oprl1 opioid receptor-like 1 75
Rat 7 367 3q43 Oprl1 opioid related nociceptin receptor 1 9,91
Previous and Unofficial Names Click here for help
N/OFQ receptor | OP4 | KOR-3 | NOCIR | kappa3-related opioid receptor | MOR-C | nociceptin receptor ORL1 | XOR1 | NOP-r | nociceptin/orphanin FQ receptor | NOPr
Database Links Click here for help
Specialist databases
GPCRdb oprx_human (Hs), oprx_mouse (Mm), oprx_rat (Rn)
Other databases
Alphafold P41146 (Hs), P35377 (Mm), P35370 (Rn)
ChEMBL Target CHEMBL2014 (Hs), CHEMBL3621 (Mm), CHEMBL4503 (Rn)
Ensembl Gene ENSG00000125510 (Hs), ENSMUSG00000027584 (Mm), ENSRNOG00000016768 (Rn)
Entrez Gene 4987 (Hs), 18389 (Mm), 29256 (Rn)
Human Protein Atlas ENSG00000125510 (Hs)
KEGG Gene hsa:4987 (Hs), mmu:18389 (Mm), rno:29256 (Rn)
OMIM 602548 (Hs)
Pharos P41146 (Hs)
RefSeq Nucleotide NM_000913 (Hs), NM_011012 (Mm), NM_031569 (Rn)
RefSeq Protein NP_000904 (Hs), NP_035142 (Mm), NP_113757 (Rn)
SynPHARM 3979 (in complex with SB 612111)
82972 (in complex with SB 612111)
UniProtKB P41146 (Hs), P35377 (Mm), P35370 (Rn)
Wikipedia OPRL1 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic
PDB Id:  4EA3
Ligand:  compound 24 [PMID: 16451050]
Resolution:  3.01Å
Species:  Human
References:  84
Natural/Endogenous Ligands Click here for help
nociceptin/orphanin FQ {Sp: Human, Mouse, Rat}
Principal endogenous agonists
nociceptin/orphanin FQ (PNOC, Q13519)  [1,8,73]

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
UFP-102 Peptide Hs Full agonist 10.7 pKd 15
⤷ pKd 10.7 [15]
[3H]Leu-N/OFQ Peptide Ligand is labelled Ligand is radioactive Hs Full agonist 10.2 pKd 57
⤷ pKd 10.2 (Kd 6x10-11 M) [57]
[3H]N/OFQ Peptide Ligand is labelled Ligand is radioactive Hs Full agonist 9.8 – 10.2 pKd 23,64
⤷ pKd 9.8 – 10.2 (Kd 1.5x10-10 – 6.3x10-11 M) [23,64]
[3H]Tyr14-N/OFQ Peptide Ligand is labelled Ligand is radioactive Mm Full agonist 10.0 pKd 1
⤷ pKd 10.0 [1]
[(pF)Phe4]N/OFQ-(1-13)-NH2 Peptide Hs Full agonist 10.8 – 11.3 pKi 8,33
⤷ pKi 10.8 – 11.3 [8,33]
N/OFQ-NH2 Peptide Hs Full agonist 10.4 pKi 57
⤷ pKi 10.4 [57]
PWT2-N/OFQ Peptide Hs Agonist 10.3 pKi 77
⤷ pKi 10.3 [77]
N/OFQ-(1-13)-NH2 Peptide Hs Full agonist 10.1 – 10.4 pKi 8,31,57,73
⤷ pKi 10.1 – 10.4 [8,31,57,73]
MCOPPB Small molecule or natural product Hs Full agonist 10.1 pKi 35
⤷ pKi 10.1 (Ki 8.6x10-11 M) [35]
Description: Binding affinity for hNOP
nociceptin/orphanin FQ {Sp: Human, Mouse, Rat} Peptide Hs Full agonist 9.7 – 10.4 pKi 1,8,73
⤷ pKi 9.7 – 10.4 [1,8,73]
(R)-Ro65-6570 Small molecule or natural product Hs Agonist 9.6 pKi 92
⤷ pKi 9.6 [92]
Ac-RYYRWK-NH2 Peptide Hs Partial agonist 9.1 – 10.0 pKi 23,57
⤷ pKi 9.1 – 10.0 (Ki 7.1x10-10 – 1x10-10 M) [23,57]
SCH221510 Small molecule or natural product Click here for species-specific activity table Hs Agonist 9.5 pKi 89
⤷ pKi 9.5 (Ki 3x10-10 M) [89]
Description: Radioligand binding assay
[Arg14Lys15]N/OFQ Peptide Hs Full agonist 9.5 pKi 72
⤷ pKi 9.5 [72]
Ro64-6198 Small molecule or natural product Hs Full agonist 9.4 pKi 42,93
⤷ pKi 9.4 [42,93]
nociceptin/orphanin FQ {Sp: Human, Mouse, Rat} Peptide Ligand is endogenous in the given species Mm Full agonist 9.4 pKi 23
⤷ pKi 9.4 [23]
SCH221510 Small molecule or natural product Rn Agonist 9.4 pKi 89
⤷ pKi 9.4 (Ki 4.2x10-10 M) [89]
Description: Radioligand binding assay
Ac-RYYRWK-NH2 Peptide Mm Partial agonist 9.2 pKi 23
⤷ pKi 9.2 [23]
[F/G]N/OFQ-(1-13)-NH2 Peptide Hs Partial agonist 9.2 pKi 57
⤷ pKi 9.2 [57]
cebranopadol Small molecule or natural product Click here for species-specific activity table Hs Agonist 9.1 pKi 49
⤷ pKi 9.1 (Ki 9x10-10 M) [49]
Description: Radioligand binding assay
cebranopadol Small molecule or natural product Click here for species-specific activity table Rn Agonist 9.0 pKi 49
⤷ pKi 9.0 (Ki 1x10-9 M) [49]
Description: Radioligand binding assay
Ac-RYYRIK-NH2 Peptide Hs Partial agonist 8.8 – 9.1 pKi 23,57
⤷ pKi 8.8 – 9.1 (Ki 1.5x10-9 – 7.9x10-10 M) [23,57]
AT-403 Small molecule or natural product Hs Agonist 9.0 pKi 3
⤷ pKi 9.0 (Ki 1.1x10-9 M) [3]
SCH221510 Small molecule or natural product Mm Agonist 8.9 pKi 89
⤷ pKi 8.9 (Ki 1.15x10-9 M) [89]
Description: Radioligand binding assay
Ac-RYYRIK-NH2 Peptide Mm Partial agonist 8.8 pKi 23
⤷ pKi 8.8 [23]
SCH486757 Small molecule or natural product Hs Agonist 8.3 pKi 58
⤷ pKi 8.3 (Ki 4.6x10-9 M) [58]
Description: Radioligand binding assay
BU08028 Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 8.1 pKi 46
⤷ pKi 8.1 (Ki 8.46x10-9 M) [46]
SR16835 Small molecule or natural product Click here for species-specific activity table Hs Agonist 7.9 pKi 86
⤷ pKi 7.9 (Ki 1.14x10-8 M) [86]
Description: Radioligand binding assay
[(pF)Phe4]N/OFQ-(1-13)-NH2 Peptide Hs Agonist 10.1 pEC50 33
⤷ pEC50 10.1 [33]
Description: Stimulation of GTP-γ35S binding
MCOPPB Small molecule or natural product Hs Full agonist 9.4 pEC50 35
⤷ pEC50 9.4 (EC50 3.9x10-10 M) [35]
Description: Potency determined in a functional assay; [35S]GTPγS recruitment
nociceptin/orphanin FQ {Sp: Human, Mouse, Rat} Peptide Hs Agonist 8.4 – 9.8 pEC50 23
⤷ pEC50 8.4 – 9.8 [23]
UFP-112 Peptide Hs Full agonist 8.4 – 9.7 pEC50 14,78
⤷ pEC50 8.4 – 9.7 [14,78]
PWT2-N/OFQ Peptide Hs Agonist 8.8 pEC50 77
⤷ pEC50 8.8 [77]
Description: Stimulation of GTP-γ35S binding
Ac-RYYRWK-NH2 Peptide Hs Agonist 8.7 pEC50 23
⤷ pEC50 8.7 (EC50 2.1x10-9 M) [23]
SCH221510 Small molecule or natural product Click here for species-specific activity table Hs Agonist 7.9 pEC50 89
⤷ pEC50 7.9 (EC50 1.2x10-8 M) [89]
Description: Stimulation of GTP-γ35S binding
cebranopadol Small molecule or natural product Click here for species-specific activity table Hs Agonist 7.9 pEC50 49
⤷ pEC50 7.9 (EC50 1.3x10-8 M) [49]
Description: Stimulation of GTP-γ35S binding
Ro64-6198 Small molecule or natural product Hs Agonist 7.4 pEC50 93
⤷ pEC50 7.4 [93]
Description: Stimulation of GTPγ35S binding
(R)-Ro65-6570 Small molecule or natural product Hs Agonist 7.4 pEC50 92
⤷ pEC50 7.4 [92]
Description: Stimulation of GTP-γ35S binding
SR16835 Small molecule or natural product Click here for species-specific activity table Hs Agonist 7.3 pEC50 86
⤷ pEC50 7.3 (EC50 4.61x10-8 M) [86]
Description: Stimulation of GTP-γ35S binding
SCH486757 Small molecule or natural product Hs Agonist 7.1 pEC50 58
⤷ pEC50 7.1 (EC50 7.9x10-8 M) [58]
Description: Stimulation of GTP-γ35S binding
Ac-RYYRIK-NH2 Peptide Hs Agonist 5.1 pEC50 23
⤷ pEC50 5.1 [23]
Description: Stimulation of GTP-γ35S binding
View species-specific agonist tables
Agonist Comments
The above affinities are based on the use of radiolabelled N/OFQ to bind to membrane preparations from CHO cells containing the NOP receptors. This represents a high affinity binding conformation in the absence of Na+ and GTP, and low affinity values are not available. The Ki in intact cells, or in the presence of Na+ and GTP analogues can be different and multiple affinity sites have been observed.

Discrimination of full or partial agonism is very dependent on the level of receptor expression and on the assay used to monitor agonist effects. For instance [Phe1ψ(CH2-NH)Gly2]NC(1-13)NH2, the first "antagonist" reported [32], has antagonist activity in the guinea pig ileum and mouse vas deferens, but partial agonist activity in transfected cells, and full agonist activity in vivo. The identification of agonist activity in the table is largely based on the ability to stimulate GTPγS binding in cell lines expressing cloned human NOP receptors and in some instances smooth muscle bioassays such as mouse or rat vas deferens. Agents giving 85% or greater stimulation than that given by N/OFQ have been characterized as Full Agonists [23,57]. Results may be different in brain membranes. In vivo and smooth muscle bioassay results may also be different and depend upon the assay performed.

Biased Agonists
There are have been two publications discussing biased agonism for the NOP receptor [16,50]. In each case compounds with less than 100% efficacy with respect to G protein coupling appeared to be ineffective for β-arrestin coupling. Furthermore, potencies of agonists for the NOP receptor/β-arrestin interaction were systematically lower that those measured for the NOP receptor/G protein interaction in both publications.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
TRAP-101 Small molecule or natural product Mm Antagonist 7.8 pA2 87
⤷ pA2 7.8 [87]
Description: Antagonism of the electrically induced twitch response in mouse vas deferens stimulated by N/OFQ as agonist.
NiK-21273 Small molecule or natural product Hs Antagonist 7.4 pKB 53
⤷ pKB 7.4 (KB 4.17x10-8 M) [53]
Description: Antagonism of N/OFQ-induced calcium mobilisation in CHO cells expressing hNOP.
UFP-101 Peptide Hs Antagonist 10.2 pKi 11
⤷ pKi 10.2 [11]
LY2940094 Small molecule or natural product Hs Antagonist 10.0 pKi 25,85
⤷ pKi 10.0 (Ki 1x10-10 M) [25,85]
compound 24 [PMID: 16451050] Small molecule or natural product Ligand has a PDB structure Hs Antagonist 9.6 pKi 26
⤷ pKi 9.6 (Ki 2.4x10-10 M) [26]
SB 612111 Small molecule or natural product Ligand has a PDB structure Hs Antagonist 9.2 – 9.5 pKi 83,95
⤷ pKi 9.2 – 9.5 [83,95]
AT-076 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.8 pKi 97
⤷ pKi 8.8 (Ki 1.75x10-9 M) [97]
Description: Radioligand binding assay
J-113397 Small molecule or natural product Hs Antagonist 8.7 pKi 74
⤷ pKi 8.7 [74]
[Nphe1]N/OFQ-(1-13)-NH2 Peptide Hs Antagonist 8.4 pKi 11
⤷ pKi 8.4 [11]
JTC-801 Small molecule or natural product Hs Antagonist 8.1 pKi 80
⤷ pKi 8.1 [80]
peptide III-BTD Peptide Hs Antagonist 7.6 pKi 4
⤷ pKi 7.6 [4]
compound 24 [PMID: 16451050] Small molecule or natural product Ligand has a PDB structure Hs Antagonist 9.6 – 10.0 pIC50 26,29
⤷ pIC50 9.6 – 10.0 (IC50 2.7x10-10 – 1x10-10 M) [26,29]
SB 612111 Small molecule or natural product Ligand has a PDB structure Hs Antagonist 8.2 – 9.7 pIC50 83,95
⤷ pIC50 8.2 – 9.7 [83,95]
J-113397 Small molecule or natural product Hs Antagonist 8.3 pIC50 45
⤷ pIC50 8.3 [45]
View species-specific antagonist tables
Antagonist Comments
The above affinities ase based on binding to receptors in membrane preparations and represent a rough average from, in some cases, multiple studies.

So far, no inverse agonists have been reported for the NOP receptor.

More details about the pharmacological profile of the NOP receptors and the chemistry of NOP ligands can be found in review articles [10,12,63,96].
Allosteric Modulator Comments
Although no small molecules are considered direct allosteric regulators of the NOP receptor, a number of proteins such as G protein-coupled receptor kinases, β-arrestins and G proteins clearly regulate receptor functions. Furthermore, sodium and guanyl nucleotides can modify the functional NOP complex and G protein interaction. Finally, other G protein-coupled receptors (i.e. the μ opioid receptor [90]) appear to be able to form heterodimers with NOP receptors, potentailly modifying the receptor activity.
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family Adenylyl cyclase inhibition
Potassium channel
Calcium channel
Other - See Comments
Comments:  NOP receptors have been shown to activate MAP kinase and phospholipase C/[Ca2+] [34].
References:  20,23,61,76,88
Secondary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family Adenylyl cyclase inhibition
References: 
Tissue Distribution Click here for help
Brain: cerebral > hippocampus, cerebellum, striatum.
Species:  Human
Technique:  Radioligand binding and in situ hybridisation.
References:  5,69
CNS: cortex, olfactory bulb, suprachiasmatic nucleus, amygdala, nucleus accumbens, thalamic nuclei, hypothalamus, hippocampus, septum, superior colliculus.
Species:  Mouse
Technique:  Radioligand binding.
References:  17-19,82
CNS
Species:  Rat
Technique:  Radioligand binding and in situ hubridisation.
References:  11,27,68,81
Tissue Distribution Comments
NOP receptors are located both pre- and post-synaptically in various areas of the CNS.

Brain: cingulate, retrosplenial, perirhinal, insular and occipital cortex, anterior and posteromedial cortical amygdaloid nuclei, basolateral amygdaloid nucleus, amygdaloid complex, posterior hippocampus, dorsal endopiriform, central medial thalamic, paraventricular, rhomboid thalamic, suprachiasmatic, ventromedial hypothalamic nuclei, mammillary complex, superficial gray layer of the superior colliculus, locus coeruleus, dorsal raphe nucleus > prefrontal, fronto-parietal, temporal, piriform cortex, dentate gyrus, anterior olfactory nucleus, olfactory tubercle, shell of nucleus accumbens, claustrum, lateral septum, laterodorsal thalamic, medial habenular, subthalamic, reuniens thalamic nuclei, subiculum, periaqueductal grey matter and pons > anterior and medial hippocampus, olfactory bulb, caudate putamen, the core of the nucleus accumbens, medial septum, ventrolateral, ventroposterolateral and mediodorsal thalamic nuclei, lateral and medial geniculate nuclei, hypothalamic area, substantia nigra, ventral tegmentum area and interpedoncular nucleus.

Like the μ opioid receptor, the NOP receptor shows very dense binding in many caudal and rostral regions, but with a notably distinct binding profile. The distinction of labelling in comparison to the classical opioid receptors is most evident in the caudate putamen, where NOP receptors are relatively low. In contrast, structures such as the suprachiasmatic nucleus have an abundant expression of NOP receptors.

Studies of the distribution of NOP receptors in humans have also been limited to autoradiography and in situ hybridisation analysis. NOP receptors in the CNS appear to have a similar distribution in rat and human. It should be noted that NOP receptors appear far sooner and in larger numbers in the developing brain than the other opioid receptors do, suggesting an important role in development [68-69].
For a review of the tissue distribution of this receptor see [65].

Spinal cord: dorsal and ventral horn.

DRG: Found on large, medium, and small dorsal root ganglia neurons.
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of musculature contraction of sections of mouse vas deferens following stimulation of the intramural nerves.
Species:  Mouse
Tissue:  Vas deferens.
Response measured:  Inhibition of electrically-evoked contractions.
References:  6,13
Measurement of adrenergic neuromuscular transmission in the rat anococcygeus muscle.
This tissue is selectively sensitive to N/OFQ and does not respond to classical opioid ligands; thus it can be considered a monoreceptor preparation.
Species:  Rat
Tissue:  Anococcygeus muscle.
Response measured:  Inhibition adrenergic motor response to electrical-field stimulation.
References:  36
Measurement of cAMP levels in CHO cells transfected with the rat NOP receptor.
Species:  Rat
Tissue:  CHO cells.
Response measured:  Inhibition of forskolin-stimulated cAMP accumulation.
References:  23
Measurement of Ca2+ channel activity in SH-SY5Y neuroblastoma cells endogenously expressing the NOP receptor.
Species:  Human
Tissue:  SH-SY5Y neuroblastoma cells.
Response measured:  Inhibition of N-type calcium current.
References:  20
Measurement of cAMP levels in BE(2)-C human neuroblastoma cells endogenously expressing the human NOP receptor.
Species:  Human
Tissue:  BE(2)-C neuroblastoma cells.
Response measured:  Inhibition of forskolin-stimulated cAMP accumulation.
References:  52
Measurement of [35S]GTPγS binding in CHO cells transfected with the mouse κ receptor.
Species:  Mouse
Tissue:  CHO cells.
Response measured:  [35S]GTPγS binding.
References:  23,88
Measurement of [35S]GTPγS binding in mouse brain preperations.
Species:  Mouse
Tissue:  Brain membranes.
Response measured:  [35S]GTPγS binding.
References:  88
Measurement of cAMP levels in CHO cells transfected with the human NOP receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Inhibition of forskolin-stimulated cAMP accumulation.
References:  61
Physiological Functions Click here for help
Inhibition of electrically-evoked muscle contraction in the vas deferens.
Species:  Mouse
Tissue:  Vas deferens.
References:  6,13
Inhibition of electrically-evoked muscle contraction of the colon.
Species:  Rat
Tissue:  Colon.
References:  59
Inhibition of electrically-evoked muscle contraction in the vas deferens.
Species:  Rat
Tissue:  Vas deferens.
References:  7
Inhibition of glutamate release.
Species:  Rat
Tissue:  Cerebrocortical slices.
References:  70
Inhibition of acetylcholine release.
Species:  Rat
Tissue:  In vivo.
References:  40
NOP agonist-induced anxiogenic activity.
Species:  Rat
Tissue:  In vivo.
References:  24
Inhibition of noradrenaline release.
Species:  Mouse
Tissue:  Cortex slices.
References:  79
Inhibition of glutamate release.
Species:  Rat
Tissue:  Cerebrocortical slices.
References:  70
Inhibition of serotonin release.
Species:  Rat
Tissue:  Neocortex.
References:  56
Contraction of the colon.
Species:  Mouse
Tissue:  Colon.
References:  59
Nociception.
Species:  Mouse
Tissue:  In vivo.
References:  38-39,61-62
NOP agonist-induced anxiolytic activity after i.c.v. or peripheral injection.
Species:  Rat
Tissue:  In vivo.
References:  42
NOP agonist-induced anxiolytic activity after i.c.v. or peripheral injection.
Species:  Mouse
Tissue:  In vivo.
References:  41
NOP agonist-induced cardiovascular depression and water diuretic activity after either i.c.v. or intravenous administration.
Species:  Rat
Tissue:  In vivo.
References:  43-44
Inhibition of opioid antinociception.
Species:  Mouse
Tissue:  In vivo i.c.v. administration
References:  61-62,76
Antinociceptive activity.
Species:  Mouse
Tissue:  In vivo, intrathecal administration
References:  30,94
Inhibition of dopamine release.
Species:  Rat
Tissue:  In vivo, measured by microdialysis
References:  22,47,67
Physiological Functions Comments
Nociception: NOP receptor agonists attenuate opiate-mediated and stress-induced analgesia when administered i.c.v. but have antinociceptive activity when administered intrathecally. Small molecule agonists and antagonists generally have little effect on pain threshold when administered alone systemically in rodents. In chronic pain states systemic administration of small molecule NOP agonists is effective for inhibition of mechanical allodynia. In non-human primates, selective NOP agonists have antinociceptive activity. NOP receptor agonists and antagonists have many behavioural functions not discussed here, for a good review on the topic see [48].
For a review on the functional architecture of the NOP receptor, including information on splice variants, see reference [60].
Physiological Consequences of Altering Gene Expression Click here for help
NOP receptor knockout mice exhibit facilitation of long-term potentiation and learning abilities.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  51
Mice lacking the gene coding for the NOP receptor (NOP-/- mice) are viable, breed well and appear to age normally.
NOP receptor knockout mice exhibit insufficient recovery of hearing ability from the adaptation to sound exposure.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  71
NOP receptor knockout mice exhibit normal sensitivity to acute nociceptive stimulation but pronociceptive phenotype in some nociceptive tests.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  21,37
NOP receptor knockout mice exhibit an antidepressant phenotype in the forced swimming assay.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  28
NOP receptor knockout mice exhibit a better locomotor performance in the rotarod test and less sensitivity to haloperidol-induced motor depression.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  54-55
NOP receptor knockout mice exhibit attenuation of morphine tolerance and dependence.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  88
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0002735 abnormal chemical nociception PMID: 12814369  9155012 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0002063 abnormal learning/memory/conditioning PMID: 9707118 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae		 MGI:97440  MP:0002734 abnormal mechanical nociception PMID: 16519664 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0002799 abnormal passive avoidance behavior PMID: 9707118 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0001413 abnormal response to new environment PMID: 9707118 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0001463 abnormal spatial learning PMID: 9707118 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0001968 abnormal touch/ nociception PMID: 9155012 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0001982 decreased chemically-elicited antinociception PMID: 9660760 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0003998 decreased thermal nociceptive threshold PMID: 12814369 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0003008 enhanced long term potentiation PMID: 9707118 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0009757 impaired behavioral response to morphine PMID: 11027224 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0001906 increased dopamine level PMID: 15030410 
Oprl1tm1Hta Oprl1tm1Hta/Oprl1tm1Hta
involves: 129S4/SvJae * C57BL/6J		 MGI:97440  MP:0004597 increased susceptibility to noise-induced hearing loss PMID: 9155012 
Oprl1tm1Dgen Oprl1tm1Dgen/Oprl1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:97440  MP:0002169 no abnormal phenotype detected
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Description:  SNP rs6010719 is associated with increased PTSD symptoms.
SNP accession:  rs6010719
References:  2
Type:  Single nucleotide polymorphism
Species:  Human
Description:  SNP rs6010718 is linked with alcoholism
SNP accession:  rs6010718

References

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