Synonyms: compound 11c [PMID: 2617910] | Ro 09-4889
Compound class:
Synthetic organic
Comment: RO0094889 is a prodrug dihydropyrimidine dehydrogenase (DPD) inhibitor that was developed by Hoffmann-La Roche [3]. RO0094889 is metabolised by enzymes secreted by tumours to produce the DPD inhibitor 5-vinyluracil. This leads to inhibition of DPD-mediated catabolic degradation of the 5-fluorouracil produced locally in tumours from capecitabine [2]. RO0094889 is orally active.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
[(2R,3R,4R,5R)-4-acetyloxy-5-(4-amino-5-ethenyl-2-oxopyrimidin-1-yl)-2-methyloxolan-3-yl] acetate |
Synonyms ![]() |
compound 11c [PMID: 2617910] | Ro 09-4889 |
Database Links ![]() |
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GtoPdb PubChem SID | 387065596 |
PubChem CID | 9840745 |
Search Google for chemical match using the InChIKey | NELWQUQCCZMRPB-UBPLGANQSA-N |
Search Google for chemicals with the same backbone | NELWQUQCCZMRPB |
UniChem Compound Search for chemical match using the InChIKey | NELWQUQCCZMRPB-UBPLGANQSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NELWQUQCCZMRPB-UBPLGANQSA-N |