[3H]A81988 [Ligand Id: 3938] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL416477 (A-81988) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin II type 1a (AT-1a) receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3948] [UniProtKB: P34976] | ||||||||
| ChEMBL | Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 10.1-10.7 | B | 10.1 | pKd | 0.08 | nM | Kd | J Med Chem (1992) 35: 3714-3717 [PMID:1433184] |
| ChEMBL | Antagonist activity at angiotensin AT1 receptor in rabbit aorta | F | 10.1 | pKd | 0.08 | nM | Kd | Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232] |
| ChEMBL | pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings | B | 10.3 | pKd | 0.05 | nM | Kd | Bioorg Med Chem Lett (1994) 4: 173-176 |
| AT1 receptor/Type-1A angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095] | ||||||||
| GtoPdb | - | - | 9.24 | pKd | 0.57 | nM | Kd | Eur J Pharmacol (1994) 267: 49-54 [PMID:8206129] |
| ChEMBL | Binding affinity against angiotensin II receptor from rat liver | B | 9.21 | pKi | 0.61 | nM | Ki | J Med Chem (1993) 36: 2676-2688 [PMID:8410980] |
| AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] | ||||||||
| GtoPdb | - | - | 9.24 | pKd | 0.57 | nM | Kd | Eur J Pharmacol (1994) 267: 49-54 [PMID:8206129] |
| ChEMBL | Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver | B | 9.12 | pKi | 0.76 | nM | Ki | J Med Chem (1992) 35: 3714-3717 [PMID:1433184] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
