[3H]A81988 [Ligand Id: 3938] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL416477 (A-81988) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin II type 1a (AT-1a) receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3948] [UniProtKB: P34976] | ||||||||
| ChEMBL | Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 10.1-10.7 | B | 10.1 | pKd | 0.08 | nM | Kd | J Med Chem (1992) 35: 3714-3717 [PMID:1433184] |
| ChEMBL | Antagonist activity at angiotensin AT1 receptor in rabbit aorta | F | 10.1 | pKd | 0.08 | nM | Kd | Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232] |
| ChEMBL | pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings | B | 10.3 | pKd | 0.05 | nM | Kd | Bioorg Med Chem Lett (1994) 4: 173-176 |
| AT1 receptor/Type-1A angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095] | ||||||||
| GtoPdb | - | - | 9.24 | pKd | 0.57 | nM | Kd | Eur J Pharmacol (1994) 267: 49-54 [PMID:8206129] |
| ChEMBL | Binding affinity against angiotensin II receptor from rat liver | B | 9.21 | pKi | 0.61 | nM | Ki | J Med Chem (1993) 36: 2676-2688 [PMID:8410980] |
| AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] | ||||||||
| GtoPdb | - | - | 9.24 | pKd | 0.57 | nM | Kd | Eur J Pharmacol (1994) 267: 49-54 [PMID:8206129] |
| ChEMBL | Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver | B | 9.12 | pKi | 0.76 | nM | Ki | J Med Chem (1992) 35: 3714-3717 [PMID:1433184] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
