ML162 [Ligand Id: 12800] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1499544 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9] | ||||||||
| ChEMBL | Inhibition of Vps34 (unknown origin) | B | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (2020) 63: 10135-10157 [PMID:32324396] |
| ChEMBL | Inhibition of Vps34 (unknown origin) interaction with PIK3 assessed as reduction in autophagy by increasing LC3 level | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2020) 63: 10135-10157 [PMID:32324396] |
| glutathione peroxidase 4/Phospholipid hydroperoxide glutathione peroxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295754] [GtoPdb: 3239] [UniProtKB: P36969] | ||||||||
| GtoPdb | - | - | 5.31 | pIC50 | 4850 | nM | IC50 | J Med Chem (2023) 66: 10036-10059 [PMID:37452764] |
| ChEMBL | Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability in presence of ferrostatin-1 | B | 5.66 | pEC50 | 2200 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 127538-127538 [PMID:32920142] |
| ChEMBL | Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability | B | 7.55 | pEC50 | 28 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 127538-127538 [PMID:32920142] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
