ME4 [Ligand Id: 1448] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL300004 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| motilin receptor/Motilin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2203] [GtoPdb: 297] [UniProtKB: O43193] | ||||||||
| GtoPdb | - | - | 6.3 | pIC50 | - | - | - | J Pharmacol Exp Ther (2005) 313: 1397-405 [PMID:15764739] |
| ChEMBL | Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5) | B | 6.65 | pIC50 | 223.87 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 835-838 |
| ChEMBL | Compound was tested for in vitro motilin receptor binding affinity | B | 8.47 | pIC50 | 3.39 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 835-838 |
| Motilin receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5306] [UniProtKB: A5A4K8] | ||||||||
| ChEMBL | Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding | B | 6.65 | pIC50 | 223.87 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1347-1352 |
| ChEMBL | Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50 | B | 8.47 | pIC50 | 3.39 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1347-1352 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
