palonosetron [Ligand Id: 7486] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1189679 (Aurothioglucose, NSC-743769, (-)-palonosetron, Palonosetron, Palonosetron, (3as, 3s)-) |
|---|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| ChEMBL | Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay | F | 5.7 | pIC50 | 1995.26 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| 5-HT3B/5-HT3A/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111332] [GtoPdb: 374, 373] [UniProtKB: O95264, P46098] | ||||||||
| ChEMBL | Binding affinity to human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysis | B | 9.74 | pKd | 0.18 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Antagonist activity at human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 9.06 | pIC50 | 0.88 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Binding affinity to human 5-HT3A receptor Y73A mutant after 24 hrs by liquid scintillation counting analysis | B | 9.06 | pKd | 0.87 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3A receptor F130A mutant after 24 hrs by liquid scintillation counting analysis | B | 9.17 | pKd | 0.67 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3A receptor Y73S mutant after 24 hrs by liquid scintillation counting analysis | B | 9.21 | pKd | 0.61 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3A receptor D165K mutant after 24 hrs by liquid scintillation counting analysis | B | 9.44 | pKd | 0.36 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human wild type 5-HT3A receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysis | B | 9.49 | pKd | 0.32 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3A receptor S163A mutant after 24 hrs by liquid scintillation counting analysis | B | 9.52 | pKd | 0.3 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3A receptor D165A mutant after 24 hrs by liquid scintillation counting analysis | B | 9.52 | pKd | 0.3 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3A receptor F130Y mutant after 24 hrs by liquid scintillation counting analysis | B | 9.59 | pKd | 0.26 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3A receptor Y73F mutant after 24 hrs by liquid scintillation counting analysis | B | 9.6 | pKd | 0.25 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3A receptor S163T mutant after 24 hrs by liquid scintillation counting analysis | B | 9.66 | pKd | 0.22 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to 5HT3A receptor | B | 10.5 | pKi | 0.03 | nM | Ki | Eur J Med Chem (2010) 45: 4746-4760 [PMID:20724042] |
| ChEMBL | Antagonist activity at human 5-HT3A receptor Y73A mutant assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 7.88 | pIC50 | 13.1 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Antagonist activity at human 5-HT3A receptor F130A mutant assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 8.36 | pIC50 | 4.4 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Antagonist activity at human 5-HT3A receptor Y73S mutant assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 8.44 | pIC50 | 3.64 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Antagonist activity at human 5-HT3 receptor expressed in CHO-K1 cells assessed as inhibition of 5-HT induced inward currents preincubated for 30 sec followed by 5HT addition for 2 sec at -60 mV holding potential by ion flux automated patch clamp assay | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2021) 64: 13279-13298 [PMID:34467765] |
| ChEMBL | Antagonist activity at human 5-HT3A receptor S163A mutant assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 8.8 | pIC50 | 1.57 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Antagonist activity at human 5-HT3A receptor D165K mutant assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Antagonist activity at human 5-HT3A receptor Y73F mutant assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 8.91 | pIC50 | 1.23 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Antagonist activity at human 5-HT3A receptor S163T mutant assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 8.99 | pIC50 | 1.02 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Antagonist activity at human wild type 5-HT3A receptor expressed in HEK293 cells assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay | B | 9.08 | pIC50 | 0.83 | nM | IC50 | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| 5-HT3B/Serotonin 3b (5-HT3b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3895] [GtoPdb: 374] [UniProtKB: O95264] | ||||||||
| ChEMBL | Binding affinity to human 5-HT3B receptor F130A mutant after 24 hrs by liquid scintillation counting analysis | B | 9.32 | pKd | 0.48 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3B receptor W90C mutant after 24 hrs by liquid scintillation counting analysis | B | 9.47 | pKd | 0.34 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3B receptor I183A mutant after 24 hrs by liquid scintillation counting analysis | B | 9.64 | pKd | 0.23 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3B receptor Y143A mutant after 24 hrs by liquid scintillation counting analysis | B | 9.74 | pKd | 0.18 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| ChEMBL | Binding affinity to human 5-HT3B receptor H73A mutant after 24 hrs by liquid scintillation counting analysis | B | 9.85 | pKd | 0.14 | nM | Kd | Bioorg Med Chem (2013) 21: 7523-7528 [PMID:24128813] |
| Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| ChEMBL | Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platform | F | 4.7 | pIC50 | 19952.62 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| Kv7.1/Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221347] [GtoPdb: 560] [UniProtKB: P15382, P51787] | ||||||||
| ChEMBL | Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using IonWorks Quattro automated patch clamp platform | F | 4.3 | pIC50 | 50118.72 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| 5-HT3A in Human [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 10.49 | pKi | 0.03 | nM | Ki | Eur J Med Chem (2010) 45: 4746-60 [PMID:20724042] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
