CDK inhibitor 4.35 [Ligand Id: 10357] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| GtoPdb | Inhibition of CDK1/cyclin B1 complex. | - | 7.05 | pKi | 90 | nM | Ki | J Med Chem (2019) 62: 4606-4623 [PMID:30943029] |
| cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| GtoPdb | Inhibition of CDK2/cyclin A2 complex. | - | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2019) 62: 4606-4623 [PMID:30943029] |
| GtoPdb | Inhibition of CDK2/cyclin E1 complex. | - | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2019) 62: 4606-4623 [PMID:30943029] |
| cyclin dependent kinase 4 in Human [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
| GtoPdb | Inhibition of CDK4/cyclin D1 complex. | - | 6.22 | pIC50 | 603 | nM | IC50 | J Med Chem (2019) 62: 4606-4623 [PMID:30943029] |
| cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
| GtoPdb | Inhibition of CDK5/cyclin p25 complex. | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2019) 62: 4606-4623 [PMID:30943029] |
| cyclin dependent kinase 9 in Human [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
| GtoPdb | Inhibition of CDK9/cyclin T1 complex. | - | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (2019) 62: 4606-4623 [PMID:30943029] |
| checkpoint kinase 2 in Human [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
| GtoPdb | - | - | 6.28 | pIC50 | 525 | nM | IC50 | J Med Chem (2019) 62: 4606-4623 [PMID:30943029] |
| casein kinase 1 delta in Human [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
| GtoPdb | - | - | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2019) 62: 4606-4623 [PMID:30943029] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
