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cyclin dependent kinase 4

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Target not currently curated in GtoImmuPdb

Target id: 1976

Nomenclature: cyclin dependent kinase 4

Abbreviated Name: CDK4

Family: CDK4 subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 303 12q14 CDK4 cyclin dependent kinase 4
Mouse - 303 10 D3 Cdk4 cyclin-dependent kinase 4
Rat - 303 7q22 Cdk4 cyclin-dependent kinase 4
Previous and Unofficial Names Click here for help
cell division protein kinase 4 | CRK3 | p34/cdk4 | PSK-J3
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
PDB Id:  2W96
Resolution:  2.3Å
Species:  Human
References:  9
Enzyme Reaction Click here for help
EC Number: 2.7.11.22

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
trilaciclib Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 10.0 pKd 3
pKd 10.0 (Kd 1x10-10 M) [3]
Description: Inhibition of CDK4/cyclin D3
R547 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 9.0 pKi 10
pKi 9.0 (Ki 1x10-9 M) [10]
Description: Assayed using CDK4/cyclin D1 complex.
example 10 [WO2018033815] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.9 pKi 2
pKi 8.9 (Ki 1.37x10-9 M) [2]
Description: Evaluated in a CDK4/Cyclin D3 mobility shift assay.
alvocidib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.2 pKi 6
pKi 7.2 (Ki 6.5x10-8 M) [6]
BMS-387032 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.0 pKi 15
pKi 6.0 (Ki 9.25x10-7 M) [15]
trilaciclib Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 9.0 pIC50 3
pIC50 9.0 (IC50 1x10-9 M) [3]
Description: Inhibition of CDK4/cyclin D1
lerociclib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.0 pIC50 28
pIC50 9.0 (IC50 1x10-9 M) [28]
Description: Inhibition of CDK4/cyclin D1
abemaciclib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.7 pIC50 13
pIC50 8.7 (IC50 2x10-9 M) [13]
Description: CDK4/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.
RGB-286638 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.4 pIC50 7
pIC50 8.4 (IC50 4x10-9 M) [7]
Description: in association with cyclin D1
Cdk4 inhibitor III Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.2 pIC50 25
pIC50 8.2 (IC50 6x10-9 M) [25]
Description: CDK4/cyclin D1 complex
ribociclib Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition 8.0 pIC50 4
pIC50 8.0 (IC50 1x10-8 M) [4]
SHR6390 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.0 pIC50 29
pIC50 8.0 (IC50 1.1x10-8 M) [29]
Ro-0505124 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.7 pIC50 11
pIC50 7.7 (IC50 2x10-8 M) [11]
palbociclib Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.4 – 8.0 pIC50 12,29
pIC50 8.0 (IC50 1.1x10-8 M) [12]
pIC50 7.4 (IC50 4.4x10-8 M) [29]
BSJ-03-204 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.6 pIC50 16
pIC50 7.6 (IC50 2.69x10-8 M) [16]
Description: Inhibition of CDK4/cyclin D1 kinase activity in a biochemical assay.
compound 9b [PMID: 18986805] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.3 pIC50 17
pIC50 7.3 (IC50 5x10-8 M) [17]
BSJ-04-132 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.3 pIC50 16
pIC50 7.3 (IC50 5.06x10-8 M) [16]
Description: Inhibition of CDK4/cyclin D1 kinase activity in a biochemical assay.
riviciclib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.2 pIC50 20
pIC50 7.2 (IC50 6.3x10-8 M) [20]
Description: CDK4/cyclin D1 complex
Cdk4 inhibitor Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.1 pIC50 31
pIC50 7.1 (IC50 7.6x10-8 M) [31]
Description: CDK4/cyclin D1 complex
voruciclib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.1 pIC50 23
pIC50 7.1 (IC50 9x10-8 M) [23]
Description: Inhibition of CDK4/cyclinD1.
AT-7519 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.0 pIC50 27
pIC50 7.0 (IC50 1x10-7 M) [27]
BSJ-03-123 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pIC50 16
pIC50 7.0 (IC50 1.06x10-7 M) [16]
Description: Inhibition of CDK4/cyclin D1 activity in a biochemical kinase assay.
milciclib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.7 – 6.8 pIC50 5,19
pIC50 6.8 (IC50 1.6x10-7 M) [5]
Description: CDK4/cyclin D1 complex
pIC50 6.7 (IC50 2.2x10-7 M) [19]
Description: In vitro inhibition of CDK4/cyclin D.
Cdk4 inhibitor II Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.7 pIC50 21
pIC50 6.7 (IC50 2x10-7 M) [21]
Description: CDK4/cyclin D1 complex used in assay
fascaplysin Small molecule or natural product Primary target of this compound Hs Inhibition 6.5 pIC50 26
pIC50 6.5 (IC50 3.5x10-7 M) [26]
Description: CDK4/cyclin D1 complex
SU9516 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.8 – 6.7 pIC50 19,22
pIC50 6.7 (IC50 2x10-7 M) [22]
Description: CDK4/cyclin D1 complex used in assay
pIC50 5.8 (IC50 1.7x10-6 M) [19]
Description: In vitro inhibition of CDK4/cyclin D.
CDK inhibitor 4.35 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.2 pIC50 18
pIC50 6.2 (IC50 6.03x10-7 M) [18]
Description: Inhibition of CDK4/cyclin D1 complex.
purvalanol A Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.1 pIC50 14
pIC50 6.1 (IC50 8.5x10-7 M) [14]
Description: CDK4/cyclin D1 complex used in assay
CGP74514A Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.5 pIC50 19
pIC50 5.5 (IC50 3x10-6 M) [19]
Description: In vitro inhibition of human CDK4/cyclin D.
Cdk2 inhibitor IV Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.3 pIC50 24
pIC50 5.3 (IC50 5.5x10-6 M) [24]
Description: CDK4/cyclin D complex used in assay
purvalanol B Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition <5.0 pIC50 14
pIC50 <5.0 (IC50 >1x10-5 M) [14]
Description: CDK4/cyclin D1 complex used in assay
Inhibitor Comments
Fascaplysin did not inhibit CDK4/cyclin D2 and CDK4/cyclin D3 at concentrations >100μM, but did inhibit CDK6/cyclin D2 but with a low affinity of 35000nM [26].
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 8,30

Key to terms and symbols Click column headers to sort
Target used in screen: CDK4-cyclinD1
Ligand Sp. Type Action Value Parameter
R547 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.2 pKd
alvocidib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.1 pKd
AT-7519 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.7 pKd
lestaurtinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 7.5 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.3 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.2 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 6.1 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
Target used in screen: CDK4-cyclinD3
Ligand Sp. Type Action Value Parameter
R547 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.1 pKd
alvocidib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.5 pKd
AT-7519 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.9 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.7 pKd
lestaurtinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 7.5 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.2 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
PHA-665752 Small molecule or natural product Hs Inhibitor Inhibition 6.4 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.4 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/CDK4/cyclin D1
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
K-252a Small molecule or natural product Hs Inhibitor Inhibition 2.9
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.0
PKR inhibitor Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2
SB 218078 Small molecule or natural product Hs Inhibitor Inhibition 11.2
alsterpaullone 2-cyanoethyl Small molecule or natural product Hs Inhibitor Inhibition 11.8
JAK3 inhibitor VI Small molecule or natural product Hs Inhibitor Inhibition 14.0
JNJ-7706621 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 20.0
Gö 6976 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 27.5
SU9516 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 33.7
dorsomorphin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 35.3
Target used in screen: nd/CDK4/cyclin D3
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
K-252a Small molecule or natural product Hs Inhibitor Inhibition 3.4
Cdk1/2 inhibitor III Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 3.7
PKR inhibitor Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.3
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 16.0
Cdk4 inhibitor Small molecule or natural product Hs Inhibitor Inhibition 21.1
JAK3 inhibitor VI Small molecule or natural product Hs Inhibitor Inhibition 21.3
SB 218078 Small molecule or natural product Hs Inhibitor Inhibition 22.2
alsterpaullone 2-cyanoethyl Small molecule or natural product Hs Inhibitor Inhibition 25.9
JNJ-7706621 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 34.7
Gö 6976 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 44.5
Displaying the top 10 most potent ligands  View all ligands in screen »
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0071353 cellular response to interleukin-4 IEA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Dedifferentiated liposarcoma
Synonyms: Liposarcoma [Disease Ontology: DOID:3382]
Disease Ontology: DOID:3382
Orphanet: ORPHA99970
Disease:  Melanoma, cutaneous malignant, susceptibility to, 3; CMM3
Synonyms: Familial melanoma [Orphanet: ORPHA618]
OMIM: 609048
Orphanet: ORPHA618
Disease:  Well-differentiated liposarcoma
Synonyms: Liposarcoma [Disease Ontology: DOID:3382]
Disease Ontology: DOID:3382
Orphanet: ORPHA99971

References

Show »

1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]

2. Behenna DC, Chen P, Freeman-Cook KD, Hoffman RL, Jalaie M, Nagata A, Nair SK, Ninkovic S, Ornelas MA, Palmer CL et al.. (2018) Pyridopyrimdinone cdk2/4/6 inhibitors. Patent number: WO2018033815A1. Assignee: Pfizer Inc.. Priority date: 15/08/2016. Publication date: 22/02/2018.

3. Bisi JE, Sorrentino JA, Roberts PJ, Tavares FX, Strum JC. (2016) Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression. Mol. Cancer Ther., 15 (5): 783-93. [PMID:26826116]

4. Brain CT, Sung MJ, Lago B. (2015) Pyrrolopyrimidine compounds and their uses. Patent number: US8962630. Assignee: Novartis Ag. Priority date: 22/08/2008. Publication date: 24/02/2015.

5. Brasca MG, Amboldi N, Ballinari D, Cameron A, Casale E, Cervi G, Colombo M, Colotta F, Croci V, D'Alessio R et al.. (2009) Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor. J. Med. Chem., 52 (16): 5152-63. [PMID:19603809]

6. Carlson BA, Dubay MM, Sausville EA, Brizuela L, Worland PJ. (1996) Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res., 56 (13): 2973-8. [PMID:8674031]

7. Cirstea D, Hideshima T, Santo L, Eda H, Mishima Y, Nemani N, Hu Y, Mimura N, Cottini F, Gorgun G et al.. (2013) Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia, 27 (12): 2366-75. [PMID:23807770]

8. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

9. Day PJ, Cleasby A, Tickle IJ, O'Reilly M, Coyle JE, Holding FP, McMenamin RL, Yon J, Chopra R, Lengauer C et al.. (2009) Crystal structure of human CDK4 in complex with a D-type cyclin. Proc. Natl. Acad. Sci. U.S.A., 106 (11): 4166-70. [PMID:19237565]

10. DePinto W, Chu XJ, Yin X, Smith M, Packman K, Goelzer P, Lovey A, Chen Y, Qian H, Hamid R et al.. (2006) In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials. Mol. Cancer Ther., 5 (11): 2644-58. [PMID:17121911]

11. Ding Q, Gillespie P, Kim K, McComas WW, Perrotta A. (2006) Diaminothiazoles having antiproliferative activity. Patent number: US7094896. Assignee: Hoffmann-La Roche Inc.. Priority date: 22/12/2001. Publication date: 22/08/2006.

12. Fry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E, Albassam M, Zheng X, Leopold WR, Pryer NK et al.. (2004) Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol. Cancer Ther., 3 (11): 1427-38. [PMID:15542782]

13. Gelbert LM, Cai S, Lin X, Sanchez-Martinez C, Del Prado M, Lallena MJ, Torres R, Ajamie RT, Wishart GN, Flack RS et al.. (2014) Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest New Drugs, 32 (5): 825-37. [PMID:24919854]

14. Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L et al.. (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science, 281 (5376): 533-8. [PMID:9677190]

15. Hole AJ, Baumli S, Shao H, Shi S, Huang S, Pepper C, Fischer PM, Wang S, Endicott JA, Noble ME. (2013) Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. J. Med. Chem., 56 (3): 660-70. [PMID:23252711]

16. Jiang B, Wang ES, Donovan KA, Liang Y, Fischer ES, Zhang T, Gray NS. (2019) Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew. Chem. Int. Ed. Engl., 58 (19): 6321-6326. [PMID:30802347]

17. Jones CD, Andrews DM, Barker AJ, Blades K, Byth KF, Finlay MR, Geh C, Green CP, Johannsen M, Walker M et al.. (2008) Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. Bioorg. Med. Chem. Lett., 18 (24): 6486-9. [PMID:18986805]

18. Jorda R, Havlíček L, Šturc A, Tušková D, Daumová L, Alam M, Škerlová J, Nekardová M, Peřina M, Pospíšil T et al.. (2019) 3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models. J. Med. Chem., 62 (9): 4606-4623. DOI: 10.1021/acs.jmedchem.9b00189 [PMID:30943029]

19. Jorda R, Hendrychová D, Voller J, Řezníčková E, Gucký T, Kryštof V. (2018) How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?. J. Med. Chem., 61 (20): 9105-9120. [PMID:30234987]

20. Joshi KS, Rathos MJ, Joshi RD, Sivakumar M, Mascarenhas M, Kamble S, Lal B, Sharma S. (2007) In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00. Mol. Cancer Ther., 6 (3): 918-25. [PMID:17363486]

21. Kubo A, Nakagawa K, Varma RK, Conrad NK, Cheng JQ, Lee WC, Testa JR, Johnson BE, Kaye FJ, Kelley MJ. (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin. Cancer Res., 5 (12): 4279-86. [PMID:10632371]

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24. Pennati M, Campbell AJ, Curto M, Binda M, Cheng Y, Wang LZ, Curtin N, Golding BT, Griffin RJ, Hardcastle IR et al.. (2005) Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol. Cancer Ther., 4 (9): 1328-37. [PMID:16170024]

25. Ryu CK, Kang HY, Lee SK, Nam KA, Hong CY, Ko WG, Lee BH. (2000) 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg. Med. Chem. Lett., 10 (5): 461-4. [PMID:10743948]

26. Soni R, Muller L, Furet P, Schoepfer J, Stephan C, Zumstein-Mecker S, Fretz H, Chaudhuri B. (2000) Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product. Biochem. Biophys. Res. Commun., 275 (3): 877-84. [PMID:10973815]

27. Squires MS, Feltell RE, Wallis NG, Lewis EJ, Smith DM, Cross DM, Lyons JF, Thompson NT. (2009) Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Mol. Cancer Ther., 8 (2): 324-32. [PMID:19174555]

28. Strum JC, Bisi JE, Roberts PJ, Tavares FX. (2016) Transient protection of normal cells during chemotherapy. Patent number: US9464092B2. Assignee: G1 Therapeutics Inc. Priority date: 15/03/2013. Publication date: 11/10/2016.

29. Sun P, Lan J, Peng J, Chen Y, Wang B, Dong Q. (2014) Thiophene miazines derivate, preparation method therefor, and medical application thereof. Patent number: WO2014183520A1. Assignee: Shanghai Hengrui Pharmaceutical Co. Priority date: 17/05/2013. Publication date: 20/11/2014.

30. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

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How to cite this page

CDK4 subfamily: cyclin dependent kinase 4. Last modified on 18/08/2020. Accessed on 24/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1976.