Synonyms: NSC 625987 | NSC-625987 | NSC625987
Compound class:
Synthetic organic
Comment: NSC 625987 was originally reported as a cyclin-dependent kinase 4 (CDK4) inhibitor, with >500-fold selectivity compared to CDK2 (IC50 >100 μM for cdc2/cyclin A, CDK2/cyclin A and CDK2/cyclin E) [4]. However, kinase profiling results reported by Jorda et al. (2018) found that no kinases tested were >50% inhibited by 10 μM NSC 625987 [3]. In addition, these authors found no evidence of CDK4 inhibition in cellular assays. Therefore, caution is advised when choosing CDK4 pharmacological tools.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
1,4-dimethoxy-9,10-dihydroacridine-9-thione |
Synonyms ![]() |
NSC 625987 | NSC-625987 | NSC625987 |
Database Links ![]() |
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CAS Registry No. | 141992-47-4 |
ChEMBL Ligand | CHEMBL1331734 |
GtoPdb PubChem SID | 178102574 |
PubChem CID | 3004085 |
Search Google for chemical match using the InChIKey | KFAKESMKRPNZTM-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | KFAKESMKRPNZTM |
UniChem Compound Search for chemical match using the InChIKey | KFAKESMKRPNZTM-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | KFAKESMKRPNZTM-UHFFFAOYSA-N |
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NSC 625987 (links to external site)
Cat. No. HY-103380 |