Cdk4 inhibitor II   

GtoPdb Ligand ID: 5951

Synonyms: NSC 625987 | NSC-625987 | NSC625987
Compound class: Synthetic organic
Comment: NSC 625987 was originally reported as a cyclin-dependent kinase 4 (CDK4) inhibitor, with >500-fold selectivity compared to CDK2 (IC50 >100 μM for cdc2/cyclin A, CDK2/cyclin A and CDK2/cyclin E) [4]. However, kinase profiling results reported by Jorda et al. (2018) found that no kinases tested were >50% inhibited by 10 μM NSC 625987 [3]. In addition, these authors found no evidence of CDK4 inhibition in cellular assays. Therefore, caution is advised when choosing CDK4 pharmacological tools.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 66.34
Molecular weight 271.07
XLogP 4.16
No. Lipinski's rules broken 0
Canonical SMILES COc1ccc(c2c1[nH]c1ccccc1c2=S)OC
Isomeric SMILES COc1ccc(c2c1[nH]c1ccccc1c2=S)OC
InChI InChI=1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013)
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Biochem. J., 451 (2): 313-28. [PMID:23398362]
3. Jorda R, Hendrychová D, Voller J, Řezníčková E, Gucký T, Kryštof V. (2018)
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?.
J. Med. Chem., 61 (20): 9105-9120. [PMID:30234987]
4. Kubo A, Nakagawa K, Varma RK, Conrad NK, Cheng JQ, Lee WC, Testa JR, Johnson BE, Kaye FJ, Kelley MJ. (1999)
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
Clin. Cancer Res., 5 (12): 4279-86. [PMID:10632371]