G1T38

Ligand id: 10313

Name: G1T38

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 91.21
Molecular weight 474.29
XLogP 4.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[[5-(4-propan-2-ylpiperazin-1-yl)pyridin-2-yl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-10-one
Synonyms
example GG [US9464092B2] | G1T-38 | lerociclib (proposed INN)
Comments
G1T38 is an investigational CDK4/6 inhibitor [3]. It is being developed to help protect non-cancerous (normal) cells (in particular, hematopoietic stem and progenitor cells, and renal cells) in patients who are undergoing DNA damaging cancer chemotherapy [1]. G1T38 was designed to be highly selective, and short and transiently-acting.
Database Links
BindingDB Ligand 253941
CAS Registry No. 1628256-23-4 (source: WHO INN list)
ChEMBL Ligand CHEMBL3904602
GtoPdb PubChem SID 381744994
PubChem CID 86269224
Search Google for chemical match using the InChIKey YPJRHEKCFKOVRT-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YPJRHEKCFKOVRT
Search UniChem for chemical match using the InChIKey YPJRHEKCFKOVRT-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone YPJRHEKCFKOVRT