G1T38

Ligand id: 10313

Name: G1T38

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 91.21
Molecular weight 474.29
XLogP 4.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Bisi JE, Sorrentino JA, Jordan JL, Darr DD, Roberts PJ, Tavares FX, Strum JC. (2017)
Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.
Oncotarget, 8 (26): 42343-42358. [PMID:28418845]
2. Stice JP, Wardell SE, Norris JD, Yllanes AP, Alley HM, Haney VO, White HS, Safi R, Winter PS, Cocce KJ et al.. (2017)
CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.
Mol. Cancer Res., 15 (6): 660-669. [PMID:28209757]
3. Strum JC, Bisi JE, Roberts PJ, Tavares FX. (2016)
Transient protection of normal cells during chemotherapy.
Patent number: US9464092B2. Assignee: G1 Therapeutics Inc. Priority date: 15/03/2013. Publication date: 11/10/2016.