G1T38

Ligand id: 10313

Name: G1T38

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 91.21
Molecular weight 474.29
XLogP 4.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Efficacy of G1T38 in preclinical models of hormone-sensitive and treatment-resistant prostate cancer has been reported [2].
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
cyclin dependent kinase 4 Hs Inhibitor Inhibition 9.0 pIC50 - 3
pIC50 9.0 (IC50 1x10-9 M) [3]
Description: Inhibition of CDK4/cyclin D1
cyclin dependent kinase 6 Hs Inhibitor Inhibition 8.3 pIC50 - 3
pIC50 8.3 (IC50 4.7x10-9 M) [3]
Description: Inhibition of CDK6/cyclin D3 complex