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CDK4 subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CDK4 and CDK6 are Ser/Thr protein kinases that are components of protein complexes that regulate progression through the G1 phase of the cell cycle. These kinases are important integrators of mitogenic and antimitogenic signals, and are oncology drug targets. CDK4/6 inhibitors are in clinical use (e.g. abemaciclib, ribociclib and palbociclib).

Enzymes

CDK4 (cyclin dependent kinase 4) C Show summary » More detailed page

CDK6 (cyclin dependent kinase 6) C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

CDK4 subfamily. Accessed on 23/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=488.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.