trilaciclib   Click here for help

GtoPdb Ligand ID: 9626

Synonyms: Cosela® | G1T28
Approved drug Immunopharmacology Ligand
trilaciclib is an approved drug (FDA (2021))
Compound class: Synthetic organic
Comment: Trilaciclib (G1T28) is a short-acting CDK4/6 inhibitor that was developed by G1 Therapeutics [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 91.21
Molecular weight 446.25
XLogP 3.65
No. Lipinski's rules broken 0
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Canonical SMILES CN1CCN(CC1)c1ccc(nc1)Nc1ncc2c(n1)n1c(c2)C(=O)NCC21CCCCC2
Isomeric SMILES CN1CCN(CC1)c1ccc(nc1)Nc1ncc2c(n1)n1c(c2)C(=O)NCC21CCCCC2
InChI InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2021))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10565 trilaciclib
Synonyms Click here for help
Cosela® | G1T28
Database Links Click here for help
CAS Registry No. 1374743-00-6 (source: WHO INN record)
DrugCentral Ligand 5442
GtoPdb PubChem SID 340590256
PubChem CID 68029831
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UniChem Connectivity Search for chemical match using the InChIKey PDGKHKMBHVFCMG-UHFFFAOYSA-N