trilaciclib [Ligand Id: 9626] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| GtoPdb | Inhibition of CDK2/cyclinA | - | 5.89 | pIC50 | 1290 | nM | IC50 | Mol Cancer Ther (2016) 15: 783-93 [PMID:26826116] |
| cyclin dependent kinase 4 in Human [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
| GtoPdb | Inhibition of CDK4/cyclin D3 | - | 10 | pKd | 0.1 | nM | Kd | Mol Cancer Ther (2016) 15: 783-93 [PMID:26826116] |
| GtoPdb | Inhibition of CDK4/cyclin D1 | - | 9 | pIC50 | 1 | nM | IC50 | Mol Cancer Ther (2016) 15: 783-93 [PMID:26826116] |
| cyclin dependent kinase 6 in Human [GtoPdb: 1978] [UniProtKB: Q00534] | ||||||||
| GtoPdb | Inhibition of CDK6/cyclin D3 | - | 8.4 | pIC50 | 4 | nM | IC50 | Mol Cancer Ther (2016) 15: 783-93 [PMID:26826116] |
| cyclin dependent kinase 7 in Human [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
| GtoPdb | Inhibition of CDK7/cyclinM/Mat1 | - | 5.33 | pIC50 | 4640 | nM | IC50 | Mol Cancer Ther (2016) 15: 783-93 [PMID:26826116] |
| cyclin dependent kinase 9 in Human [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
| GtoPdb | Inhibition of CDK9/cyclinT | - | 7.3 | pIC50 | 50 | nM | IC50 | Mol Cancer Ther (2016) 15: 783-93 [PMID:26826116] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
