trilaciclib [Ligand Id: 9626] activity data from GtoPdb

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  • cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
  • This target only has 0 pki data point
1 _lig_chart_1 cyclin dependent kinase 2 Human
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  • cyclin dependent kinase 4 in Human [GtoPdb: 1976] [UniProtKB: P11802]
  • This target only has 0 pki data point
2 _lig_chart_2 cyclin dependent kinase 4 Human
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  • cyclin dependent kinase 6 in Human [GtoPdb: 1978] [UniProtKB: Q00534]
  • This target only has 0 pki data point
3 _lig_chart_3 cyclin dependent kinase 6 Human
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  • cyclin dependent kinase 7 in Human [GtoPdb: 1979] [UniProtKB: P50613]
  • This target only has 0 pki data point
4 _lig_chart_4 cyclin dependent kinase 7 Human
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  • cyclin dependent kinase 9 in Human [GtoPdb: 1981] [UniProtKB: P50750]
  • This target only has 0 pki data point
5 _lig_chart_5 cyclin dependent kinase 9 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb Inhibition of CDK2/cyclinA - 5.89 pIC50 1290 nM IC50 Mol. Cancer Ther. (2016) 15: 783-93 [PMID:26826116]
cyclin dependent kinase 4 in Human [GtoPdb: 1976] [UniProtKB: P11802]
GtoPdb Inhibition of CDK4/cyclin D3 - 10 pKd 0.1 nM Kd Mol. Cancer Ther. (2016) 15: 783-93 [PMID:26826116]
GtoPdb Inhibition of CDK4/cyclin D1 - 9 pIC50 1 nM IC50 Mol. Cancer Ther. (2016) 15: 783-93 [PMID:26826116]
cyclin dependent kinase 6 in Human [GtoPdb: 1978] [UniProtKB: Q00534]
GtoPdb Inhibition of CDK6/cyclin D3 - 8.4 pIC50 4 nM IC50 Mol. Cancer Ther. (2016) 15: 783-93 [PMID:26826116]
cyclin dependent kinase 7 in Human [GtoPdb: 1979] [UniProtKB: P50613]
GtoPdb Inhibition of CDK7/cyclinM/Mat1 - 5.33 pIC50 4640 nM IC50 Mol. Cancer Ther. (2016) 15: 783-93 [PMID:26826116]
cyclin dependent kinase 9 in Human [GtoPdb: 1981] [UniProtKB: P50750]
GtoPdb Inhibition of CDK9/cyclinT - 7.3 pIC50 50 nM IC50 Mol. Cancer Ther. (2016) 15: 783-93 [PMID:26826116]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.