balanol [Ligand Id: 8142] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL60254 (Balanol)
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  • beta adrenergic receptor kinase 2/Beta-adrenergic receptor kinase 2 in Human [ChEMBL: CHEMBL1075166] [GtoPdb: 1467] [UniProtKB: P35626]
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  • protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
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  • Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
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  • beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098]
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  • G protein-coupled receptor kinase 4 in Human [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298]
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  • G protein-coupled receptor kinase 6 in Human [ChEMBL: CHEMBL6144] [GtoPdb: 1470] [UniProtKB: P43250]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase C eta/Protein kinase C eta in Human [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
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  • protein kinase C gamma/Protein kinase C gamma in Human [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
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  • protein kinase C zeta/Protein kinase C zeta in Human [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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  • protein kinase A in Rat [GtoPdb: 1694]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-adrenergic receptor kinase 1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3711550] [UniProtKB: P21146]
ChEMBL Inhibition of bovine GRK2 S670A mutant expressed in Baculovirus expression system assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preincubated for 30 mins followed by ATP addition and light exposure measured after 5 to 10 mins by SDS-PAGE analysis B 7.46 pIC50 35 nM IC50 J Med Chem (2016) 59: 9277-9294 [PMID:27362616]
beta adrenergic receptor kinase 2/Beta-adrenergic receptor kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075166] [GtoPdb: 1467] [UniProtKB: P35626]
ChEMBL Inhibition of GRK3-mediated bovine tubulin phosphorylation by scintillation counting B 7.33 pIC50 47 nM IC50 J Med Chem (2010) 53: 1867-1870 [PMID:20128603]
GtoPdb - - 7.33 pIC50 47 nM IC50 J Med Chem (2010) 53: 1867-70 [PMID:20128603]
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
ChEMBL Binding affinity to PKAalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintillation spectrometry B 8.41 pKd 3.9 nM Kd J Med Chem (2016) 59: 9277-9294 [PMID:27362616]
ChEMBL Inhibitory concentration against recombinant human cAMP-dependent Protein kinase A B 7.3 pIC50 50 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
ChEMBL Binding affinity to human recombinant N-terminal GST-tagged PKGalpha expressed in Baculovirus infected insect Sf9 cells using RKRSRAE as substrate in presence of [gamma-32P]ATP B 8.8 pKd 1.6 nM Kd J Med Chem (2016) 59: 9277-9294 [PMID:27362616]
beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098]
ChEMBL Inhibition of GRK2-mediated bovine tubulin phosphorylation by scintillation counting B 7.38 pIC50 42 nM IC50 J Med Chem (2010) 53: 1867-1870 [PMID:20128603]
GtoPdb Inhibition of tubulin phosphorylation by balanol. - 7.38 pIC50 42 nM IC50 J Med Chem (2010) 53: 1867-70 [PMID:20128603]
G protein-coupled receptor kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298]
ChEMBL Inhibition of GRK4-mediated bovine tubulin phosphorylation by scintillation counting B 6.59 pIC50 260 nM IC50 J Med Chem (2010) 53: 1867-1870 [PMID:20128603]
GtoPdb Measuring inhibition of human GRK-4-mediated phosphorylation of bovine tubulin dimers. - 6.59 pIC50 260 nM IC50 J Med Chem (2010) 53: 1867-70 [PMID:20128603]
G protein-coupled receptor kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5678] [GtoPdb: 1469] [UniProtKB: P34947]
ChEMBL Inhibition of GRK5-mediated bovine tubulin phosphorylation by scintillation counting B 6.8 pIC50 160 nM IC50 J Med Chem (2010) 53: 1867-1870 [PMID:20128603]
G protein-coupled receptor kinase 5 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879830] [UniProtKB: P43249]
ChEMBL Inhibition of bovine C-terminal truncated GRK5 (561 residues) assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preincubated for 30 mins followed by ATP addition and light exposure measured after 5 to 10 mins by SDS-PAGE analysis B 6.36 pIC50 440 nM IC50 J Med Chem (2016) 59: 9277-9294 [PMID:27362616]
G protein-coupled receptor kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6144] [GtoPdb: 1470] [UniProtKB: P43250]
ChEMBL Inhibition of GRK6-mediated bovine tubulin phosphorylation by scintillation counting B 6.31 pIC50 490 nM IC50 J Med Chem (2010) 53: 1867-1870 [PMID:20128603]
GtoPdb - - 6.31 pIC50 490 nM IC50 J Med Chem (2010) 53: 1867-70 [PMID:20128603]
G protein-coupled receptor kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075133] [GtoPdb: 1471] [UniProtKB: Q8WTQ7]
GtoPdb - - 6.74 pIC50 180 nM IC50 J Med Chem (2010) 53: 1867-70 [PMID:20128603]
ChEMBL Inhibition of GRK7-mediated bovine tubulin phosphorylation by scintillation counting B 6.74 pIC50 180 nM IC50 J Med Chem (2010) 53: 1867-1870 [PMID:20128603]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Binding affinity to PKCalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintillation spectrometry B 8.19 pKd 6.4 nM Kd J Med Chem (2016) 59: 9277-9294 [PMID:27362616]
ChEMBL Inhibition of Protein kinase C alpha expressed in Sf-9 cells B 7.13 pIC50 74 nM IC50 Bioorg Med Chem Lett (1995) 5: 2133-2138
ChEMBL Inhibition of human Protein kinase C alpha B 7.13 pIC50 74 nM IC50 Bioorg Med Chem Lett (1995) 5: 2151-2154
ChEMBL Inhibition of human Protein kinase C alpha B 7.15 pIC50 70 nM IC50 Bioorg Med Chem Lett (1995) 5: 2155-2160
ChEMBL Inhibition of Protein kinase C alpha B 7.17 pIC50 67 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
GtoPdb - - 7.52 pIC50 30 nM IC50 J Med Chem (1996) 39: 5215-27 [PMID:8978850]
ChEMBL Inhibitory concentration against recombinant human Protein kinase C alpha isozyme B 7.52 pIC50 30 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
ChEMBL Evaluated against recombinant human Protein kinase C alpha B 7.52 pIC50 30 nM IC50 J Med Chem (1996) 39: 5215-5227 [PMID:8978850]
ChEMBL Inhibition of Protein kinase C alpha B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Binding affinity to PKCbeta2 (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintillation spectrometry B 8.74 pKd 1.8 nM Kd J Med Chem (2016) 59: 9277-9294 [PMID:27362616]
ChEMBL Inhibition of Protein kinase C beta 2 expressed in Sf-9 cells B 7.36 pIC50 44 nM IC50 Bioorg Med Chem Lett (1995) 5: 2133-2138
ChEMBL Inhibition of human Protein kinase C beta 2 B 7.36 pIC50 44 nM IC50 Bioorg Med Chem Lett (1995) 5: 2151-2154
ChEMBL Inhibition of human Protein kinase C beta 2 B 7.4 pIC50 40 nM IC50 Bioorg Med Chem Lett (1995) 5: 2155-2160
ChEMBL Inhibition of human Protein kinase C beta 1 B 7.49 pIC50 32 nM IC50 Bioorg Med Chem Lett (1995) 5: 2151-2154
ChEMBL Inhibition of Protein kinase C beta 2 B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Inhibition of Protein kinase C beta 1 B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Inhibition of human Protein kinase C beta 1 B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (1995) 5: 2155-2160
GtoPdb - - 8 pIC50 10 nM IC50 J Med Chem (1996) 39: 5215-27 [PMID:8978850]
ChEMBL Evaluated against recombinant human Protein kinase C beta 1 B 8 pIC50 10 nM IC50 J Med Chem (1996) 39: 5215-5227 [PMID:8978850]
ChEMBL Evaluated against recombinant human Protein kinase C beta 2 B 8 pIC50 10 nM IC50 J Med Chem (1996) 39: 5215-5227 [PMID:8978850]
ChEMBL Inhibitory concentration against recombinant human Protein kinase C beta 2 isozyme B 8 pIC50 10 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
ChEMBL Inhibition of Protein kinase C beta 1 B 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Inhibitory concentration against recombinant human Protein kinase C beta 1 isozyme B 8 pIC50 10 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
ChEMBL Inhibition of Protein kinase C beta 2 B 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Inhibition of Protein kinase C delta expressed in Sf-9 cells B 7.49 pIC50 32 nM IC50 Bioorg Med Chem Lett (1995) 5: 2133-2138
ChEMBL Inhibition of human Protein kinase C delta B 7.49 pIC50 32 nM IC50 Bioorg Med Chem Lett (1995) 5: 2151-2154
ChEMBL Inhibition of human Protein kinase C delta B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (1995) 5: 2155-2160
ChEMBL Inhibition of Protein kinase C delta B 7.64 pIC50 23 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Evaluated against recombinant human Protein kinase C delta B 7.7 pIC50 20 nM IC50 J Med Chem (1996) 39: 5215-5227 [PMID:8978850]
ChEMBL Inhibition of Protein kinase C delta B 7.8 pIC50 16 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
GtoPdb - - 7.8 pIC50 16 nM IC50 J Med Chem (1996) 39: 5215-27 [PMID:8978850]
ChEMBL Inhibitory concentration against recombinant human Protein kinase C delta isozyme B 8.4 pIC50 4 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of Protein kinase C epsilon B 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (1995) 5: 2155-2160
ChEMBL Inhibition of protein kinase C epsilon expressed in Sf-9 cells B 7.31 pIC50 49 nM IC50 Bioorg Med Chem Lett (1995) 5: 2133-2138
ChEMBL Inhibition of human Protein kinase C epsilon B 7.31 pIC50 49 nM IC50 Bioorg Med Chem Lett (1995) 5: 2151-2154
ChEMBL Inhibition of Protein kinase C epsilon B 7.42 pIC50 38 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Inhibition of Protein kinase C epsilon B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Evaluated against recombinant human Protein kinase C epsilon B 7.7 pIC50 20 nM IC50 J Med Chem (1996) 39: 5215-5227 [PMID:8978850]
GtoPdb - - 7.7 pIC50 20 nM IC50 J Med Chem (1996) 39: 5215-27 [PMID:8978850]
ChEMBL Inhibitory concentration against recombinant human Protein kinase C epsilon isozyme B 8 pIC50 10 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
ChEMBL Inhibition of Protein kinase C eta expressed in Sf-9 cells B 7.66 pIC50 22 nM IC50 Bioorg Med Chem Lett (1995) 5: 2133-2138
ChEMBL Inhibition of human protein kinase C eta B 7.66 pIC50 22 nM IC50 Bioorg Med Chem Lett (1995) 5: 2151-2154
ChEMBL Inhibition of Protein kinase C eta B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Inhibition of Protein Kinase C eta B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (1995) 5: 2155-2160
GtoPdb - - 8.52 pIC50 3 nM IC50 J Med Chem (1996) 39: 5215-27 [PMID:8978850]
ChEMBL Inhibitory concentration against recombinant human Protein kinase C eta isozyme B 8.52 pIC50 3 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
ChEMBL Evaluated against recombinant human Protein kinase C eta B 8.52 pIC50 3 nM IC50 J Med Chem (1996) 39: 5215-5227 [PMID:8978850]
ChEMBL Inhibition of Protein kinase C eta B 8.52 pIC50 3 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
ChEMBL Inhibition of human Protein kinase C gamma B 7.47 pIC50 34 nM IC50 Bioorg Med Chem Lett (1995) 5: 2151-2154
ChEMBL Inhibition of Protein kinase C gamma B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Inhibition of Protein Kinase C gamma B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (1995) 5: 2155-2160
ChEMBL Inhibitory concentration against recombinant human Protein kinase C gamma isozyme B 7.7 pIC50 20 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
GtoPdb - - 8 pIC50 10 nM IC50 J Med Chem (1996) 39: 5215-27 [PMID:8978850]
ChEMBL Inhibition of Protein kinase C gamma B 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Evaluated against recombinant human Protein kinase C gamma B 8 pIC50 10 nM IC50 J Med Chem (1996) 39: 5215-5227 [PMID:8978850]
protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
ChEMBL Inhibitory concentration against recombinant human Protein kinase C zeta isozyme B 5.13 pIC50 7400 nM IC50 J Med Chem (1997) 40: 226-235 [PMID:9003521]
ChEMBL Inhibition of Protein kinase C zeta B 5.23 pIC50 5900 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
GtoPdb - - 5.23 pIC50 5900 nM IC50 J Med Chem (1996) 39: 5215-27 [PMID:8978850]
ChEMBL Inhibition of Protein kinase C zeta B 5.46 pIC50 3500 nM IC50 Bioorg Med Chem Lett (1995) 5: 2151-2154
ChEMBL Inhibition of Protein kinase C zeta B 5.46 pIC50 3500 nM IC50 Bioorg Med Chem Lett (1995) 5: 2015-2020
ChEMBL Inhibition of Protein kinase C zeta B 5.46 pIC50 3500 nM IC50 Bioorg Med Chem Lett (1995) 5: 2155-2160
G protein-coupled receptor kinase 1/Rhodopsin kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835]
ChEMBL Inhibition of GRK1-mediated bovine tubulin phosphorylation by scintillation counting B 6.47 pIC50 340 nM IC50 J Med Chem (2010) 53: 1867-1870 [PMID:20128603]
GtoPdb - - 6.47 pIC50 340 nM IC50 J Med Chem (2010) 53: 1867-70 [PMID:20128603]
Rhodopsin kinase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879860] [UniProtKB: P28327]
ChEMBL Inhibition of bovine C-terminal truncated GRK1 (535 residues) assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preincubated for 30 mins followed by ATP addition and light exposure measured after 5 to 10 mins by SDS-PAGE analysis B 5.39 pIC50 4100 nM IC50 J Med Chem (2016) 59: 9277-9294 [PMID:27362616]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Inhibition of src Protein Tyrosine Kinase B 5 pIC50 >10000 nM IC50 J Med Chem (1996) 39: 5215-5227 [PMID:8978850]
protein kinase A in Rat [GtoPdb: 1694]
GtoPdb Inhibition of PKA extracted from rat brain homogenate. - 10.4 pIC50 0.04 nM IC50 J Med Chem (1996) 39: 5215-27 [PMID:8978850]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]