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ChEMBL ligand: CHEMBL52 (Actinex, CHX-100, MESO-NDGA, Nordihydroguaiaretic acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-lipoxygenase in Solanum tuberosum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3317] [UniProtKB: O49150] | ||||||||
ChEMBL | Inhibitory activity against potato 5LOX | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2006) 49: 1668-1683 [PMID:16509583] |
synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] | ||||||||
ChEMBL | Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay | B | 6.66 | pIC50 | 220 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
ChEMBL | Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay | B | 6.68 | pIC50 | 210 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
ChEMBL | Displacement of 5-iodoacetamidofluorescein labeled SRC23 peptide CKENALLRYLLDKDD human androgen receptor AF2 site expressed in Escherichia coli BL21 cells by fluorescence polarization assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2011) 54: 8563-8573 [PMID:22047606] |
ChEMBL | Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis | B | 4.41 | pIC50 | 38800 | nM | IC50 | J Med Chem (2011) 54: 8563-8573 [PMID:22047606] |
ChEMBL | Displacement of [3H]DHT from human androgen receptor expressed in Escherichia coli BL21 cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 8563-8573 [PMID:22047606] |
12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054] | ||||||||
ChEMBL | Inhibition of human platelet N-terminal His6-tagged 12-lipoxygenase by UV-vis spectrometry | B | 5.23 | pIC50 | 5900 | nM | IC50 | J Nat Prod (2009) 72: 1857-1863 [PMID:19848434] |
ChEMBL | Inhibitory activity against human platelet 12-lipoxygenase (12-HLO) | B | 5.29 | pIC50 | 5100 | nM | IC50 | J Med Chem (2002) 45: 2659-2661 [PMID:12036375] |
ChEMBL | Inhibitory activity against human platelet 12-lipoxygenase | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 93-96 |
ChEMBL | Inhibition of 12-hLO | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
ChEMBL | Inhibition of His-tagged human platelet 12-lipoxygenase | B | 6.74 | pIC50 | 180 | nM | IC50 | J Nat Prod (2003) 66: 230-235 [PMID:12608855] |
ChEMBL | Inhibition of human platelet-type 12-lipoxygenase | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2011) 54: 5485-5497 [PMID:21739938] |
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] | ||||||||
ChEMBL | Inhibition of human 15-lipoxygenase | B | 5.29 | pIC50 | 5100 | nM | IC50 | J Med Chem (2011) 54: 5485-5497 [PMID:21739938] |
ChEMBL | Inhibitory activity against rabbit reticulocyte 15-lipoxygenase was evaluated by measuring inhibition of the conversion of linoleic acid to hydroperoxide | B | 5.31 | pIC50 | 4900 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 93-96 |
ChEMBL | Inhibition of 15 LOX | B | 5.42 | pIC50 | 3800 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4026-4029 [PMID:17502145] |
ChEMBL | Inhibition of human reticulocyte N-terminal His6-tagged 15-lipoxygenase by UV-vis spectrometry | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Nat Prod (2009) 72: 1857-1863 [PMID:19848434] |
ChEMBL | Inhibition of 15-hLO1 | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
ChEMBL | Inhibition of human reticulocyte 12/15-lipoxygenase using arachidonic acid/linoleic acid as substrate by fluorescence assay | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2014) 57: 4035-4048 [PMID:24684213] |
ChEMBL | Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO) | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2002) 45: 2659-2661 [PMID:12036375] |
ChEMBL | Inhibition of His-tagged human reticulocyte 15-lipoxygenase | B | 6.96 | pIC50 | 110 | nM | IC50 | J Nat Prod (2003) 66: 230-235 [PMID:12608855] |
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
ChEMBL | Inhibitory concentration against isolated rabbit reticulocyte 15-lipoxygenase measured in the presence of linoleic acid | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1435-1440 [PMID:15713402] |
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] | ||||||||
ChEMBL | Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins in dark by ferric ion oxidation-xylenol orange assay | B | 4.87 | pIC50 | 13600 | nM | IC50 | J Nat Prod (2019) 82: 3311-3320 [PMID:31774676] |
ChEMBL | Inhibition of 15-hLO2 | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] | ||||||||
ChEMBL | Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay | B | 4.46 | pIC50 | 35000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4195-4198 [PMID:18541424] |
ChEMBL | Inhibition of 5-LOX (unknown origin) after 5 mins by colorimetric method | B | 4.9 | pIC50 | 12500 | nM | IC50 | Eur J Med Chem (2020) 200: 112438-112438 [PMID:32485533] |
ChEMBL | Inhibition of 5-lipoxygenase | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem (2010) 18: 5807-5815 [PMID:20667741] |
ChEMBL | Inhibition of 5-lipoxygenase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Nat Prod (1998) 61: 347-350 [PMID:9544564] |
ChEMBL | Inhibition of 5LOX | B | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg Med Chem (2008) 16: 10332-10337 [PMID:18976930] |
ChEMBL | Inhibition against 5-lipoxygenase from guinea pig polymorphonuclear lymphocytes | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (1990) 33: 1186-1194 [PMID:2157009] |
ChEMBL | Inhibition of 5LOX in human PBMC by EIA assay | B | 6.89 | pIC50 | 130 | nM | IC50 | J Nat Prod (2007) 70: 859-862 [PMID:17378609] |
ChEMBL | Inhibition of human 5-LOX in human peripheral blood mononuclear leukocytes assessed as inhibition of calymycin A23187-stimulated LTB4 production preincubated for 15 mins before stimulation measured after 15 mins by enzyme immunoassay | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem (2011) 19: 6340-6347 [PMID:21958738] |
ChEMBL | Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometry | B | 6.96 | pIC50 | 110 | nM | IC50 | J Nat Prod (2009) 72: 1857-1863 [PMID:19848434] |
ChEMBL | Inhibition of human 5-lipoxygenase using arachidonic acid as substrate pretreated for 10 mins followed by substrate and ATP addition and measured after 20 mins by H2DCFDA probe based fluorescence assay | B | 7 | pIC50 | 100 | nM | IC50 | Eur J Med Chem (2018) 156: 534-553 [PMID:30025348] |
ChEMBL | Inhibition of human 5-Lipoxygenase using H2DCFDA as substrate preincubated for 5 mins and measured by Spectrophotometric assay | B | 7.01 | pIC50 | 97 | nM | IC50 | Eur J Med Chem (2020) 190: 112090-112090 [PMID:32018096] |
ChEMBL | Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compound | F | 7.07 | pIC50 | 85 | nM | IC50 | J Med Chem (1989) 32: 1190-1197 [PMID:2542553] |
ChEMBL | Inhibition of recombinant human 5-LOX in human PBML assessed as inhibition of A23187-induced LTB4 production preincubated for 15 mins measured after 15 mins by enzyme immunoassay | B | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem (2011) 19: 6316-6328 [PMID:21958737] |
Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] | ||||||||
ChEMBL | Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes | F | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (1993) 36: 4099-4107 [PMID:8258834] |
ChEMBL | Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL). | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1993) 36: 4099-4107 [PMID:8258834] |
5-LOX/Arachidonate 5-lipoxygenase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5211] [GtoPdb: 1385] [UniProtKB: P48999] | ||||||||
ChEMBL | Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins before stimulation measured after 2 hrs by ELISA | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem (2011) 19: 6340-6347 [PMID:21958738] |
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
ChEMBL | The compound was tested for inhibitory activity against 5-Lipoxygenase in rat blood | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (1992) 35: 2501-2524 [PMID:1635053] |
ChEMBL | In vitro inhibition of LTB4 production was measured in rat blood | F | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (1991) 34: 1028-1036 [PMID:1848292] |
ChEMBL | Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation) | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1990) 33: 2744-2749 [PMID:2213827] |
ChEMBL | In vitro inhibitory concentration against 5-lipoxygenase in RBL-1 cells | B | 6.39 | pIC50 | 410 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 845-848 [PMID:11277534] |
ChEMBL | In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1991) 34: 2158-2165 [PMID:2066989] |
ChEMBL | Inhibitory activity against rat basophilic leukemia cell 5-lipoxygenase | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 93-96 |
ChEMBL | In vitro inhibitory activity against RBL-1 5-LO | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1987) 30: 574-580 [PMID:3820229] |
ChEMBL | In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay) | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1990) 33: 2744-2749 [PMID:2213827] |
ChEMBL | Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (1990) 33: 360-370 [PMID:2104936] |
ChEMBL | In vitro inhibition of RBL-1 5-lipoxygenase | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1987) 30: 2216-2221 [PMID:3681891] |
ChEMBL | Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatant | F | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (1996) 39: 246-252 [PMID:8568814] |
ChEMBL | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1993) 36: 3904-3909 [PMID:8254620] |
ChEMBL | Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 339-344 |
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664] | ||||||||
ChEMBL | Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLC | B | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem (2009) 17: 558-568 [PMID:19097798] |
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
ChEMBL | Inhibition of COX2 in LPS-stimulated human blood | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2009) 17: 558-568 [PMID:19097798] |
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
ChEMBL | Inhibition of human placental microsome CYP19 | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 3050-3064 [PMID:20413308] |
Estradiol 17-beta-dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3181] [UniProtKB: P14061] | ||||||||
ChEMBL | Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting method | B | 5.26 | pIC50 | 5500 | nM | IC50 | J Nat Prod (2017) 80: 965-974 [PMID:28319389] |
hydroxysteroid 17-beta dehydrogenase 2/Estradiol 17-beta-dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2789] [GtoPdb: 3094] [UniProtKB: P37059] | ||||||||
ChEMBL | Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation counting method | B | 6.42 | pIC50 | 380 | nM | IC50 | J Nat Prod (2017) 80: 965-974 [PMID:28319389] |
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Inhibition of IGF1R | B | 6.05 | pIC50 | 900 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4026-4029 [PMID:17502145] |
BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
ChEMBL | The compound was tested for its inhibitory activity against LTB4 in human PMN | B | 7.07 | pIC50 | 85 | nM | IC50 | J Med Chem (1992) 35: 1299-1318 [PMID:1313879] |
Lipoxygenase in Glycine max (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641359] [UniProtKB: Q39829] | ||||||||
ChEMBL | Inhibition of soybean LOX assessed as reduction in conversion of sodium linoleate to 13-hydroperoxylinoleic acid by UV spectroscopy | B | 4.29 | pIC50 | 51000 | nM | IC50 | Bioorg Med Chem (2014) 22: 6586-6594 [PMID:25456384] |
ChEMBL | Inhibition of soybean LOX using sodium linoleate as substrate by spectrophotometry | B | 4.55 | pIC50 | 28000 | nM | IC50 | Eur J Med Chem (2014) 86: 502-514 [PMID:25203780] |
ChEMBL | Inhibition of soybean lipoxygenase | B | 4.55 | pIC50 | 28000 | nM | IC50 | Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112] |
ChEMBL | Inhibition of soybean lipoxygenase after 5 mins by colorimetric assay | B | 5.03 | pIC50 | 9230 | nM | IC50 | Bioorg Med Chem (2014) 22: 4151-4161 [PMID:24938495] |
ChEMBL | Inhibition of soybean lipoxygenase using sodium linoleate as substrate by UV-based analysis | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2019) 62: 2184-2201 [PMID:30715875] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.1 | pIC50 | 7943.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
Plasmodium yoelii yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612328] | ||||||||
ChEMBL | Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs | F | 4.52 | pIC50 | 30000 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 1215-1220 [PMID:18212104] |
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] | ||||||||
ChEMBL | MERS_3CL Pro protease inhibition IC50 by FRET kind of response from peptide substrate | F | 5 | pIC50 | >10000 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] | ||||||||
ChEMBL | SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate | F | 5.59 | pIC50 | 2590 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
Seed lipoxygenase-1 in Glycine max (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4586] [UniProtKB: P08170] | ||||||||
ChEMBL | Inhibition of soybean LOX type 1 pre-incubated for 4 mins at 7x10'-7 w/v concentration assessed as inhibition of sodium linoleate to 13-hydroperoxylinoleic acid | B | 4.5 | pIC50 | 31300 | nM | IC50 | Eur J Med Chem (2012) 47: 111-124 [PMID:22119153] |
ChEMBL | In vitro inhibitory activity against 5-lipoxygenase obtained from potato | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4842-4845 [PMID:16143531] |
ChEMBL | In vitro inhibitory activity against 15-lipoxygenase obtained from soybean | B | 5.46 | pIC50 | 3500 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4842-4845 [PMID:16143531] |
ChEMBL | Inhibitory activity against soybean 15LOX | B | 5.46 | pIC50 | 3500 | nM | IC50 | J Med Chem (2006) 49: 1668-1683 [PMID:16509583] |
ChEMBL | Inhibition of soybean lipoxygenase after 7 mins | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2007) 15: 951-961 [PMID:17126019] |
ChEMBL | Inhibitory activity against soybean 1-lipoxygenase (SLO) | B | 6.74 | pIC50 | 180 | nM | IC50 | J Med Chem (2002) 45: 2659-2661 [PMID:12036375] |
Transcription factor AP1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111421] [UniProtKB: P01100, P05412] | ||||||||
ChEMBL | Inhibition of Fos-Jun dimer formation (unknown origin) | B | 8.1 | pIC50 | 7.9 | nM | IC50 | J Med Chem (2014) 57: 6930-6948 [PMID:24831826] |
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.45 | pEC50 | 35481.34 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.46 | pEC50 | 35000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Calcium-5 dye based fluorescence assay | B | 5.31 | pEC50 | 4900 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
ChEMBL | Inhibition of TTR L55P mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assay | B | 4.9 | pEC50 | 12600 | nM | EC50 | J Med Chem (2014) 57: 8928-8935 [PMID:25314129] |
ChEMBL | Inhibition of TTR I84T mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assay | B | 5.07 | pEC50 | 8500 | nM | EC50 | J Med Chem (2014) 57: 8928-8935 [PMID:25314129] |
ChEMBL | Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assay | B | 5.14 | pEC50 | 7300 | nM | EC50 | J Med Chem (2014) 57: 8928-8935 [PMID:25314129] |
Uncharacterized protein in Solanum lycopersicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105968] [UniProtKB: K4CF70] | ||||||||
ChEMBL | Inhibition of recombinant Solanum lycopersicum (tomato) fatty acid 13-hydroperoxide lyase using (13S)-HPOT substrate by spectrophotometry | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Pestic Sci (2011) 36: 58-62 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]