Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	387	16q23.3	HSD17B2	hydroxysteroid 17-beta dehydrogenase 2
Mouse	1	381	8 E1	Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2
Rat	-	381	19q12	Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2

Previous and Unofficial Names

17β-HSD2 | estradiol 17-beta-dehydrogenase 2 | HSD17 | SDR9C2 | short chain dehydrogenase/reductase family 9C, member 2

Database Links
Alphafold	P37059 (Hs), P51658 (Mm)
BRENDA	1.1.1.62, 1.1.1.239
ChEMBL Target	CHEMBL2789 (Hs), CHEMBL1914270 (Mm)
Ensembl Gene	ENSG00000086696 (Hs), ENSMUSG00000031844 (Mm), ENSRNOG00000013982 (Rn)
Entrez Gene	3294 (Hs), 15486 (Mm), 79243 (Rn)
Human Protein Atlas	ENSG00000086696 (Hs)
KEGG Enzyme	1.1.1.62, 1.1.1.239
KEGG Gene	hsa:3294 (Hs), mmu:15486 (Mm), rno:79243 (Rn)
OMIM	109685 (Hs)
Pharos	P37059 (Hs)
RefSeq Nucleotide	NM_002153 (Hs), NM_008290 (Mm), NM_024391 (Rn)
RefSeq Protein	NP_002144 (Hs), NP_032316 (Mm), NP_077367 (Rn)
UniProtKB	P37059 (Hs), P51658 (Mm)
Wikipedia	HSD17B2 (Hs)

Enzyme Reaction
EC Number: 1.1.1.62 17β-estradiol + NAD+ = estrone + H+ + NADH EC Number: 1.1.1.239

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 24 [PMID: 31343176] Hs Inhibition 8.2 pIC50 1 ⤷ pIC50 8.2 (IC50 6.1x10-9 M) [1] compound 24 [PMID: 31343176] Rn Inhibition 8.0 pIC50 1 ⤷ pIC50 8.0 (IC50 1x10-8 M) [1] compound 24 [PMID: 31343176] Mm Inhibition 7.7 pIC50 1 ⤷ pIC50 7.7 (IC50 2.2x10-8 M) [1]
View species-specific inhibitor tables

General Comments

17β-HSD2 catalyses the interconversion of estradiol <-> estrone and testosterone <-> androstenedione. Pharmacological inhibition of 17β-HSD2 is being investigated as a novel mechanism for the treatment of osteoporosis. Inhibiting 17β-HSD2 is predicted to increase estradiol and testosterone levels in bone, and to thereby simultaneously inhibit osteoclast-mediated bone resorption and increase bone formation by osteoblasts.