Top ▲

CoV Non-structural protein 15

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 3206

Nomenclature: CoV Non-structural protein 15

Family: Coronavirus (CoV) proteins

Previous and Unofficial Names Click here for help
NendoU | NSP15
Database Links Click here for help
UniProtKB
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA
PDB Id:  7TJ2
Resolution:  3.2Å
Species:  SARS-CoV-2
References:  1
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of SARS-CoV-2 NendoU in complex with FUZS-5
PDB Id:  5S71
Ligand:  FUZS-5
Resolution:  1.94Å
Species:  SARS-CoV-2
References:  2
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of SARS-CoV-2 NendoU in complex with LIZA-7
PDB Id:  7N7U
Ligand:  LIZA-7
Resolution:  2.06Å
Species:  SARS-CoV-2
References:  2

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
tipiracil Small molecule or natural product Approved drug SARS-CoV-2 Inhibition - - 3
[3]

References

Show »

1. Frazier MN, Wilson IM, Krahn JM, Butay KJ, Dillard LB, Borgnia MJ, Stanley RE. (2022) Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease. Nucleic Acids Res, 50 (14): 8290-8301. [PMID:35801916]

2. Godoy AS, Nakamura AM, Douangamath A, Song Y, Noske GD, Gawriljuk VO, Fernandes RS, Pereira HDM, Oliveira KIZ, Fearon D et al.. (2022) Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. bioRxiv, Preprint. DOI: 10.1101/2022.09.26.509485

3. Kim Y, Wower J, Maltseva N, Chang C, Jedrzejczak R, Wilamowski M, Kang S, Nicolaescu V, Randall G, Michalska K et al.. (2021) Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol, 4 (1): 193. [PMID:33564093]

How to cite this page