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Coronavirus (CoV) proteins

Overview

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Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 years as serious human pathogens: SARS-CoV was identified as the causative agent in an outbreak in 2002-2003, Middle East respiratory syndrome (MERS) CoV emerged in 2012 and the novel coronavirus SARS-CoV-2 emerged in 2019-2020. SARS-CoV-2 is the virus responsible for the infectious disease termed COVID-19 (WHO Technical Guidance 2020).

Targets

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CoV Envelope protein Show summary » More detailed page go icon to follow link

CoV 3C-like (main) protease Show summary » More detailed page go icon to follow link

CoV Membrane glycoprotein Show summary » More detailed page go icon to follow link

CoV Non-structural protein 6 Show summary » More detailed page go icon to follow link

CoV Non-structural protein 7b Show summary » More detailed page go icon to follow link

CoV Non-structural protein 8 Show summary » More detailed page go icon to follow link

CoV Nucleoprotein Show summary » More detailed page go icon to follow link

CoV Papain-like protease Show summary » More detailed page go icon to follow link

CoV Protein 3a Show summary » More detailed page go icon to follow link

CoV Protein 7a Show summary » More detailed page go icon to follow link

CoV Protein 9b Show summary » More detailed page go icon to follow link

CoV Replicase polyprotein 1a Show summary » More detailed page go icon to follow link

CoV Replicase polyprotein 1ab Show summary » More detailed page go icon to follow link

CoV RNA-dependent RNA polymerase Show summary » More detailed page go icon to follow link

CoV Spike glycoprotein Show summary » More detailed page go icon to follow link

Comments

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.