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Coronavirus (CoV) proteins

Overview

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Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 years as serious human pathogens: SARS-CoV was identified as the causative agent in an outbreak in 2002-2003, Middle East respiratory syndrome (MERS) CoV emerged in 2012 and the novel coronavirus SARS-CoV-2 emerged in 2019-2020. SARS-CoV-2 is the virus responsible for the infectious disease termed COVID-19 (WHO Technical Guidance 2020).

Targets

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CoV Envelope protein Show summary » More detailed page go icon to follow link

CoV 3C-like (main) protease Show summary » More detailed page go icon to follow link

CoV Membrane glycoprotein Show summary » More detailed page go icon to follow link

CoV Non-structural protein 6 Show summary » More detailed page go icon to follow link

CoV Non-structural protein 7b Show summary » More detailed page go icon to follow link

CoV Non-structural protein 8 Show summary » More detailed page go icon to follow link

CoV Non-structural protein 14 Show summary » More detailed page go icon to follow link

CoV Nucleoprotein Show summary » More detailed page go icon to follow link

CoV Papain-like protease Show summary » More detailed page go icon to follow link

CoV Protein 3a Show summary » More detailed page go icon to follow link

CoV Protein 7a Show summary » More detailed page go icon to follow link

CoV Protein 9b Show summary » More detailed page go icon to follow link

CoV Replicase polyprotein 1a Show summary » More detailed page go icon to follow link

CoV Replicase polyprotein 1ab Show summary » More detailed page go icon to follow link

CoV RNA-dependent RNA polymerase Show summary » More detailed page go icon to follow link

CoV Spike glycoprotein Show summary » More detailed page go icon to follow link

Comments

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.