SARS-CoV-2 Protein 9b | SARS-CoV-2 proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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SARS-CoV-2 Protein 9b

Target not currently curated in GtoImmuPdb

Target id: 3122

Nomenclature: SARS-CoV-2 Protein 9b

Family: SARS-CoV-2 proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
SARS-CoV-2 - 97 orf1ab
Previous and Unofficial Names
orf9b | Accessory protein 9b | ORF-9b
Database Links
Entrez Gene
UniProtKB
General Comments
SARS-CoV protein 9b is a virion-associated accessory protein [2]. It appears to localise to host cell mitochondria. Protein 9b activates the MAVS signalosome and triggers the degradation of MAVS, TRAF3, and TRAF6 [1]. This profoundly limits the host's ability to mount an antiviral IFN-induced innate immune response. By homology, 9b from SARS-CoV-2 would be predicted to exhibit a similar function.

References

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1. Shi CS, Qi HY, Boularan C, Huang NN, Abu-Asab M, Shelhamer JH, Kehrl JH. (2014) SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome. J. Immunol., 193 (6): 3080-9. [PMID:25135833]

2. Xu K, Zheng BJ, Zeng R, Lu W, Lin YP, Xue L, Li L, Yang LL, Xu C, Dai J et al.. (2009) Severe acute respiratory syndrome coronavirus accessory protein 9b is a virion-associated protein. Virology, 388 (2): 279-85. [PMID:19394665]

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