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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| SARS-CoV-2 | - | 97 | ORF9b | Protein 9b | ||
| SARS-CoV | - | 98 | ORF9b | Protein 9b | ||
| Previous and Unofficial Names |
| orf9b | Accessory protein 9b | ORF-9b |
| Database Links |
|
| Entrez Gene | 43740578 (SARS-CoV-2), 1489679 (SARS-CoV) |
| UniProtKB | P0DTD2 (SARS-CoV-2), P59636 (SARS-CoV) |
| General Comments |
| SARS-CoV protein 9b is a virion-associated accessory protein [2]. It appears to localise to host cell mitochondria. Protein 9b activates the MAVS signalosome and triggers the degradation of MAVS, TRAF3, and TRAF6 [1]. This profoundly limits the host's ability to mount an antiviral IFN-induced innate immune response. By homology, 9b from SARS-CoV-2 would be predicted to exhibit a similar function. |
1. Shi CS, Qi HY, Boularan C, Huang NN, Abu-Asab M, Shelhamer JH, Kehrl JH. (2014) SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome. J Immunol, 193 (6): 3080-9. [PMID:25135833]
2. Xu K, Zheng BJ, Zeng R, Lu W, Lin YP, Xue L, Li L, Yang LL, Xu C, Dai J et al.. (2009) Severe acute respiratory syndrome coronavirus accessory protein 9b is a virion-associated protein. Virology, 388 (2): 279-85. [PMID:19394665]
