SARS-CoV-2 Non-structural protein 6 | SARS-CoV-2 proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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SARS-CoV-2 Non-structural protein 6

Target not currently curated in GtoImmuPdb

Target id: 3118

Nomenclature: SARS-CoV-2 Non-structural protein 6

Family: SARS-CoV-2 proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
SARS-CoV-2 - 290 orf1ab
Previous and Unofficial Names
nsp6
Database Links
Entrez Gene
RefSeq Protein
UniProtKB
General Comments
Coronavirus nsp6 proteins limit autophagosome expansion [1]. This mechanism may favour coronavirus infection by damaging autophagosome-mediated delivery of viral components to lysosomes for degradation.

References

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1. Cottam EM, Whelband MC, Wileman T. (2014) Coronavirus NSP6 restricts autophagosome expansion. Autophagy, 10 (8): 1426-41. [PMID:24991833]

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