SARS-CoV-2 Protein non-structural 7b | SARS-CoV-2 proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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SARS-CoV-2 Protein non-structural 7b

Target not currently curated in GtoImmuPdb

Target id: 3123

Nomenclature: SARS-CoV-2 Protein non-structural 7b

Family: SARS-CoV-2 proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
SARS-CoV-2 - 43 orf1ab
Previous and Unofficial Names
nsp7b | Accessory protein 7b
Database Links
Entrez Gene
UniProtKB
General Comments
Protein 7b is a coronavirus accessory protein. It is a single-pass transmembrane protein. Investigations using a naturally occurring variant of SARS-CoV with a deletion in protein 7b (Frankfurt-1 strain) suggests that 7b has some attenuating function during the early phase of infection [1]. The deletion variant conferred increased virulence but did not alter infection capacity. By homology, SARS-CoV-2 7b is likely to have a similar function.

References

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1. Pfefferle S, Krähling V, Ditt V, Grywna K, Mühlberger E, Drosten C. (2009) Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo. Virol. J., 6: 131. [PMID:19698190]

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