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CoV Non-structural protein 7b

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Target not currently curated in GtoImmuPdb

Target id: 3123

Nomenclature: CoV Non-structural protein 7b

Family: Coronavirus (CoV) proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
SARS-CoV-2 1 43 ORF7b Non-structural protein 7b
SARS-CoV 1 44 Orf7b Non-structural protein 7b
Previous and Unofficial Names Click here for help
Accessory protein 7b | nsp7b
Database Links Click here for help
Entrez Gene
RefSeq Protein
UniProtKB
General Comments
Protein 7b is a coronavirus accessory protein. It is a single-pass transmembrane protein. Investigations using a naturally occurring variant of SARS-CoV with a deletion in protein 7b (Frankfurt-1 strain) suggests that 7b has some attenuating function during the early phase of infection [1]. The deletion variant conferred increased virulence but did not alter infection capacity. By homology, SARS-CoV-2 7b is likely to have a similar function.

References

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1. Pfefferle S, Krähling V, Ditt V, Grywna K, Mühlberger E, Drosten C. (2009) Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo. Virol. J., 6: 131. [PMID:19698190]

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