Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Gene and Protein Information Comments
SARS-CoV RdRp is a 932 amino acid protein that is amino acids 4370-5301 of the polyprotein encoded by Orf1b. SARS-CoV-2 RdRp is a 932 amino acid protein that is amino acids 4393-5324 of the polyprotein encoded by Orf1b.

Previous and Unofficial Names

non-structural protein 12 | nsp12

Database Links
ChEMBL Target	CHEMBL5118 (SARS-CoV)
UniProtKB	P0DTD1 (SARS-CoV-2), P0C6X7 (SARS-CoV)

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Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference remdesivir SARS-CoV-2 Inhibition - - 1 ⤷ [1] remdesivir SARS-CoV Inhibition - - 1 ⤷ [1]
View species-specific inhibitor tables

General Comments

Although RdRp is strictly a component of the SARS-CoV-2 replicase polyprotein we have included it as a separate entity to allow us to more sensibly curate pharmacological information (particularly regarding inhibitor development) that is specific for this enzyme. RdRP functions as a component of a genome replication protein complex that also contains nsp7 and nsp8 [2-3]. RdRP-mediated replication can be primer-dependent, but RdRp is also capable of de novo (primer-independent) RNA synthesis. Because of the conserved structure of the key drug-binding pockets between SARS-CoV-2, SARS-CoV, and MERS-CoV RdRPs, repurposing known SARS-CoV and MERS-CoV inhibitors for SARS-CoV-2 is an obvious strategy to combat SARS-CoV-2. To enhance therapeutic efficacy a sensible strategy would be to develop a multi-targeted combination of RdRP inhibitors with approved or clinical-stage drug candidates against other viral and/or host proteins. Although RdRp is strictly a component of the SARS-CoV replicase polyprotein we have included it as a separate entity to allow us to more sensibly curate pharmacological information (particularly regarding inhibitor development) that is specific for this enzyme.RdRP functions as a component of a genome replication protein complex that also contains nsp7 and nsp8 [2-3]. RdRP-mediated replication can be primer-dependent, but RdRp is also capable of de novo (primer-independent) RNA synthesis. It has been suggested that nsp8 is a second, non-canonical RdRP that generates short primers that are used by nsp12 canonical RdRp for primer-dependent RNA synthesis [2].