SARS-CoV-2 Non-structural protein 8 | SARS-CoV-2 proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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SARS-CoV-2 Non-structural protein 8

Target not currently curated in GtoImmuPdb

Target id: 3120

Nomenclature: SARS-CoV-2 Non-structural protein 8

Family: SARS-CoV-2 proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
SARS-CoV-2 - 198 orf1ab
Previous and Unofficial Names
nsp8
Database Links
Entrez Gene
RefSeq Protein
UniProtKB
General Comments
Coronavirus nsp8 proteins form a hexadecameric complex with nsp7 proteins (8 subunits of each) [1,3]. This complex may participate in viral replication by acting as a primase for de novo initiation of RNA synthesis, and is also able to extend primed RNA templates. Cryo-EM resolution of the SARS-CoV-2 polymerase complex architecture shows that it contains the nsp12 catalytic subunit and nsp7-nsp8 co-factors [2].

References

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1. Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE, Canard B. (2006) A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J., 25 (20): 4933-42. [PMID:17024178]

2. Peng Q, Peng R, Yuan B, Zhao J, Wang M, Wang X, Sun Y, Fan Z, Qi J, Gao GF et al.. (2020) Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2. Cell Reports,. DOI: 10.1016/j.celrep.2020.107774

3. te Velthuis AJ, van den Worm SH, Snijder EJ. (2012) The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension. Nucleic Acids Res., 40 (4): 1737-47. [PMID:22039154]

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