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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| SARS-CoV-2 | - | 121 | Non-structural protein 8 | |||
| Previous and Unofficial Names |
| nsp8 |
| Database Links |
|
| Entrez Gene | 43740577 (SARS-CoV-2) |
| RefSeq Protein | YP_009724396 (SARS-CoV-2) |
| UniProtKB | P0DTC8 (SARS-CoV-2) |
| General Comments |
| Coronavirus nsp8 proteins form a hexadecameric complex with nsp7 proteins (8 subunits of each) [1,3]. This complex may participate in viral replication by acting as a primase for de novo initiation of RNA synthesis, and is also able to extend primed RNA templates. Cryo-EM resolution of the SARS-CoV-2 polymerase complex architecture shows that it contains the nsp12 catalytic subunit and nsp7-nsp8 co-factors [2]. |
1. Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE, Canard B. (2006) A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J, 25 (20): 4933-42. [PMID:17024178]
2. Peng Q, Peng R, Yuan B, Zhao J, Wang M, Wang X, Sun Y, Fan Z, Qi J, Gao GF et al.. (2020) Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2. Cell Reports,. DOI: 10.1016/j.celrep.2020.107774
3. te Velthuis AJ, van den Worm SH, Snijder EJ. (2012) The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension. Nucleic Acids Res, 40 (4): 1737-47. [PMID:22039154]
