SARS-CoV-2 Protein 7a | SARS-CoV-2 proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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SARS-CoV-2 Protein 7a

Target not currently curated in GtoImmuPdb

Target id: 3119

Nomenclature: SARS-CoV-2 Protein 7a

Family: SARS-CoV-2 proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
SARS-CoV-2 - 121 ORF7a
Previous and Unofficial Names
orf7a
Database Links
Entrez Gene
RefSeq Protein
UniProtKB
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  STRUCTURE OF THE SARS-CORONAVIRUS ORF7A ACCESSORY PROTEIN.
PDB Id:  1XAK
Resolution:  1.8Å
Species:  None
References:  1
General Comments
The SARS-CoV protein 7a has no significant sequence homology with any other known viral or non-viral proteins. Sequence analysis predicts that ORF 7a encodes a type I transmembrane protein, and a crystal structure reveals that its luminal domain is topologically immunoglobulin-like [1]. SARS-CoV 7a is an accessory protein that is dispensible for virus replication. It's main function appears to be disruption of the host cell cycle and induction of caspase-dependent apoptosis [2]. Co-precipitation of 7a and host Ap4A-hydrolase reveals another interaction that may cause cell cycle arrest and apoptosis [3]. By homology SARS-CoV-2 protein 7a is likely to perform a similar function(s).

References

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1. Nelson CA, Pekosz A, Lee CA, Diamond MS, Fremont DH. (2005) Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein. Structure, 13 (1): 75-85. [PMID:15642263]

2. Tan YJ, Fielding BC, Goh PY, Shen S, Tan TH, Lim SG, Hong W. (2004) Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. J. Virol., 78 (24): 14043-7. [PMID:15564512]

3. Vasilenko N, Moshynskyy I, Zakhartchouk A. (2010) SARS coronavirus protein 7a interacts with human Ap4A-hydrolase. Virol. J., 7: 31. [PMID:20144233]

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