NS6740 [Ligand Id: 11383] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2380804
  • nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
ChEMBL Displacement of [3H]A-585539 from rat brain alpha7 nAChR by scintillation counting analysis B 8.96 pKi 1.1 nM Ki Bioorg. Med. Chem. (2013) 21: 2635-2642 [PMID:23507153]
GtoPdb Binding affinity to rat brain α7 nAChR, measured by displacement of the α7-selective agonist [3H]A-585539. - 8.96 pKi 1.1 nM Ki Br J Pharmacol (2009) 158: 1486-94 [PMID:19845675]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]