NS6740 [Ligand Id: 11383] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2380804 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941] | ||||||||
| ChEMBL | Displacement of [3H]A-585539 from rat brain alpha7 nAChR by scintillation counting analysis | B | 8.96 | pKi | 1.1 | nM | Ki | Bioorg Med Chem (2013) 21: 2635-2642 [PMID:23507153] |
| GtoPdb | Binding affinity to rat brain α7 nAChR, measured by displacement of the α7-selective agonist [3H]A-585539. | - | 8.96 | pKi | 1.1 | nM | Ki | Br J Pharmacol (2009) 158: 1486-94 [PMID:19845675] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
