ChEMBL ligand: CHEMBL415247 (Jdtic, Rti-jdtic)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting	B	6.73	pKi	188	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
ChEMBL	Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in HEK cells after 60 mins	B	7.44	pKi	36.11	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
ChEMBL	Binding affinity towards human cloned Opioid receptor delta 1 using [3H]Cl-DPDPE	B	7.53	pKi	29.6	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	6.42	pEC50	380	nM	EC50	J Med Chem (2010) 53: 5290-5301 [PMID:20568781]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain tissue	B	6.52	pKi	301	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Binding affinity of compound for opioid receptor delta 1 was determined using [3H]DADLE as radioligand from rat brain tissue	B	6.52	pKi	301	nM	Ki	J Med Chem (2004) 47: 1070-1073 [PMID:14761209]
ChEMBL	Displacement of [3H]DADLE from delta-opioid receptor in rat brain membranes after 2 hrs	B	6.52	pKi	>300	nM	Ki	Eur J Med Chem (2017) 141: 632-647 [PMID:29107424]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Displacement of [3H]-astemizole from human ERG	B	5.05	pKi	8820	nM	Ki	Bioorg Med Chem (2015) 23: 6379-6388 [PMID:26342544]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Antagonist activity at human KOR assessed as inhibition of U69593-stimulated [35S]GTPgammaS binding	F	10.46	pKd	0.03	nM	Kd	J Med Chem (2013) 56: 2178-2195 [PMID:23360448]
ChEMBL	Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593	B	9.39	pKi	0.41	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
GtoPdb	-	-	9.4	pKi	0.4	nM	Ki	ACS Chem Neurosci (2015) 6: 646-57 [PMID:25635572]; J Med Chem (2001) 44: 2687-90 [PMID:11495579]; PLoS ONE (2013) 8: e70701 [PMID:23976952]
ChEMBL	Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting	B	10.23	pKi	0.06	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
ChEMBL	Antagonist activity at kappa opioid receptor (unknown origin)	B	10.52	pKi	0.03	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
ChEMBL	Antagonist activity at kappa opioid receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS	F	11	pKi	0.01	nM	Ki	Eur J Med Chem (2017) 141: 632-647 [PMID:29107424]
GtoPdb	Measuring antagonism of U50,488-induced [35S]GTPγS binding	-	11.22	pKi	0.01	nM	Ki	J Med Chem (2001) 44: 2687-90 [PMID:11495579]
ChEMBL	Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	8.22	pEC50	6	nM	EC50	J Med Chem (2010) 53: 5290-5301 [PMID:20568781]
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
ChEMBL	Displacement of [3H]U69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins	B	9.49	pKi	0.32	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brain	B	9.49	pKi	0.32	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Binding affinity of compound for Opioid receptor kappa 1 was determined using [3H]U-69593 as radioligand from guinea pig caudate	B	9.49	pKi	0.32	nM	Ki	J Med Chem (2004) 47: 1070-1073 [PMID:14761209]
ChEMBL	Antagonist activity at kappa opioid receptor in guinea pig caudate assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] binding	F	10.7	pKi	0.02	nM	Ki	Bioorg Med Chem Lett (2014) 24: 2021-2032 [PMID:24690494]
ChEMBL	Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes after 2 hrs	B	10.7	pKi	0.02	nM	Ki	Eur J Med Chem (2017) 141: 632-647 [PMID:29107424]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting	B	7.94	pKi	11.5	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
ChEMBL	Displacement of [3H]diprenorphine from human recombinant mu opioid receptor expressed in HEK cells after 60 mins	B	8.4	pKi	4	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
ChEMBL	Binding affinity towards human cloned Opioid receptor mu 1 using [3H]DAMGO	B	9.02	pKi	0.96	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	6.92	pEC50	120	nM	EC50	J Med Chem (2010) 53: 5290-5301 [PMID:20568781]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of rat brain tissue	B	8.43	pKi	3.73	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Binding affinity of compound for Opioid receptor mu 1 was determined using [3H]DAMGO as radioligand from rat brain tissue	B	8.43	pKi	3.73	nM	Ki	J Med Chem (2004) 47: 1070-1073 [PMID:14761209]
ChEMBL	Displacement of [3H]DAMGO from mu-opioid receptor in rat brain membranes after 2 hrs	B	8.67	pKi	2.16	nM	Ki	Eur J Med Chem (2017) 141: 632-647 [PMID:29107424]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Antagonist activity at mu opioid receptor in guinea pig caudate assessed as inhibition of DAMGO-stimulated [35S]-GTP[gammaS] binding	F	8.67	pKi	2.16	nM	Ki	Bioorg Med Chem Lett (2014) 24: 2021-2032 [PMID:24690494]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]