ChEMBL ligand: CHEMBL415247 (Jdtic, Rti-jdtic)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting	B	6.73	pKi	188	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
ChEMBL	Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in HEK cells after 60 mins	B	7.44	pKi	36.11	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
ChEMBL	Binding affinity towards human cloned Opioid receptor delta 1 using [3H]Cl-DPDPE	B	7.53	pKi	29.6	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	6.42	pEC50	380	nM	EC50	J Med Chem (2010) 53: 5290-5301 [PMID:20568781]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain tissue	B	6.52	pKi	301	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Binding affinity of compound for opioid receptor delta 1 was determined using [3H]DADLE as radioligand from rat brain tissue	B	6.52	pKi	301	nM	Ki	J Med Chem (2004) 47: 1070-1073 [PMID:14761209]
ChEMBL	Displacement of [3H]DADLE from delta-opioid receptor in rat brain membranes after 2 hrs	B	6.52	pKi	>300	nM	Ki	Eur J Med Chem (2017) 141: 632-647 [PMID:29107424]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Displacement of [3H]-astemizole from human ERG	B	5.05	pKi	8820	nM	Ki	Bioorg Med Chem (2015) 23: 6379-6388 [PMID:26342544]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Antagonist activity at human KOR assessed as inhibition of U69593-stimulated [35S]GTPgammaS binding	F	10.46	pKd	0.03	nM	Kd	J Med Chem (2013) 56: 2178-2195 [PMID:23360448]
ChEMBL	Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593	B	9.39	pKi	0.41	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
GtoPdb	-	-	9.4	pKi	0.4	nM	Ki	ACS Chem Neurosci (2015) 6: 646-57 [PMID:25635572]; J Med Chem (2001) 44: 2687-90 [PMID:11495579]; PLoS ONE (2013) 8: e70701 [PMID:23976952]
ChEMBL	Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting	B	10.23	pKi	0.06	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
ChEMBL	Antagonist activity at kappa opioid receptor (unknown origin)	B	10.52	pKi	0.03	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
ChEMBL	Antagonist activity at kappa opioid receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS	F	11	pKi	0.01	nM	Ki	Eur J Med Chem (2017) 141: 632-647 [PMID:29107424]
GtoPdb	Measuring antagonism of U50,488-induced [35S]GTPγS binding	-	11.22	pKi	0.01	nM	Ki	J Med Chem (2001) 44: 2687-90 [PMID:11495579]
ChEMBL	Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	8.22	pEC50	6	nM	EC50	J Med Chem (2010) 53: 5290-5301 [PMID:20568781]
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
ChEMBL	Displacement of [3H]U69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins	B	9.49	pKi	0.32	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brain	B	9.49	pKi	0.32	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Binding affinity of compound for Opioid receptor kappa 1 was determined using [3H]U-69593 as radioligand from guinea pig caudate	B	9.49	pKi	0.32	nM	Ki	J Med Chem (2004) 47: 1070-1073 [PMID:14761209]
ChEMBL	Antagonist activity at kappa opioid receptor in guinea pig caudate assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] binding	F	10.7	pKi	0.02	nM	Ki	Bioorg Med Chem Lett (2014) 24: 2021-2032 [PMID:24690494]
ChEMBL	Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes after 2 hrs	B	10.7	pKi	0.02	nM	Ki	Eur J Med Chem (2017) 141: 632-647 [PMID:29107424]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting	B	7.94	pKi	11.5	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
ChEMBL	Displacement of [3H]diprenorphine from human recombinant mu opioid receptor expressed in HEK cells after 60 mins	B	8.4	pKi	4	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
ChEMBL	Binding affinity towards human cloned Opioid receptor mu 1 using [3H]DAMGO	B	9.02	pKi	0.96	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	6.92	pEC50	120	nM	EC50	J Med Chem (2010) 53: 5290-5301 [PMID:20568781]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of rat brain tissue	B	8.43	pKi	3.73	nM	Ki	J Med Chem (2003) 46: 3127-3137 [PMID:12825951]
ChEMBL	Binding affinity of compound for Opioid receptor mu 1 was determined using [3H]DAMGO as radioligand from rat brain tissue	B	8.43	pKi	3.73	nM	Ki	J Med Chem (2004) 47: 1070-1073 [PMID:14761209]
ChEMBL	Displacement of [3H]DAMGO from mu-opioid receptor in rat brain membranes after 2 hrs	B	8.67	pKi	2.16	nM	Ki	Eur J Med Chem (2017) 141: 632-647 [PMID:29107424]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Antagonist activity at mu opioid receptor in guinea pig caudate assessed as inhibition of DAMGO-stimulated [35S]-GTP[gammaS] binding	F	8.67	pKi	2.16	nM	Ki	Bioorg Med Chem Lett (2014) 24: 2021-2032 [PMID:24690494]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]