ChEMBL ligand: CHEMBL203619
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2] There should be some charts here, you may need to enable JavaScript!
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] There should be some charts here, you may need to enable JavaScript!
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
ChEMBL	Inhibition of MLK7	B	6.15	pIC50	708	nM	IC50	J Med Chem (2006) 49: 2138-2142 [PMID:16539403]
GtoPdb	-	-	6.15	pIC50	708	nM	IC50	J Med Chem (2006) 49: 2138-42 [PMID:16539403]
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
GtoPdb	-	-	7.1	pIC50	79	nM	IC50	J Med Chem (2006) 49: 2138-42 [PMID:16539403]
ChEMBL	Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells	B	7.1	pIC50	79	nM	IC50	J Med Chem (2006) 49: 2138-2142 [PMID:16539403]
ChEMBL	Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells	F	7.1	pIC50	79	nM	IC50	J Med Chem (2006) 49: 2138-2142 [PMID:16539403]
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
GtoPdb	-	-	6.45	pIC50	352	nM	IC50	J Med Chem (2006) 49: 2138-42 [PMID:16539403]
ChEMBL	Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells	B	6.45	pIC50	352	nM	IC50	J Med Chem (2006) 49: 2138-2142 [PMID:16539403]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]