compound 15b [PMID: 16539403] [Ligand Id: 8194] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL203619
  • ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
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  • transforming growth factor beta receptor 1/TGF-beta receptor type I in Human [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
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  • transforming growth factor beta receptor 2/TGF-beta receptor type II in Human [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
ChEMBL Inhibition of MLK7 B 6.15 pIC50 708 nM IC50 J Med Chem (2006) 49: 2138-2142 [PMID:16539403]
GtoPdb - - 6.15 pIC50 708 nM IC50 J Med Chem (2006) 49: 2138-42 [PMID:16539403]
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
GtoPdb - - 7.1 pIC50 79 nM IC50 J Med Chem (2006) 49: 2138-42 [PMID:16539403]
ChEMBL Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells B 7.1 pIC50 79 nM IC50 J Med Chem (2006) 49: 2138-2142 [PMID:16539403]
ChEMBL Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells F 7.1 pIC50 79 nM IC50 J Med Chem (2006) 49: 2138-2142 [PMID:16539403]
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
GtoPdb - - 6.45 pIC50 352 nM IC50 J Med Chem (2006) 49: 2138-42 [PMID:16539403]
ChEMBL Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells B 6.45 pIC50 352 nM IC50 J Med Chem (2006) 49: 2138-2142 [PMID:16539403]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]