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Synonyms: BAF-312 | BAF312 | compound 32 [PMID: 24900670] | Mayzent®
siponimod is an approved drug (FDA (2019), EMA (2020))
Compound class: Synthetic organic
Comment: Pharmacologically, siponimod (BAF312) is a selective sphingosine-1-phosphate (S1P) receptor agonist, with some selectivity for the S1P1 and S1P5 receptor isoforms . It is an orally active drug. Siponimod was developed by Novartis for secondary progressive multiple sclerosis (SPMS), originally as a back-up compound for fingolimod. Compared to fingolimod it has more favourable pharmacokinetics.
Novartis announced positive results from their Phase 3 EXPAND study (BAF312 versus placebo) in SPMS (August 2016- link to announcement here).
The SIPR signalling pathway is important in autoimmune biology.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Approved drug?||Yes (FDA (2019), EMA (2020))|
|International Nonproprietary Names|
|BAF-312 | BAF312 | compound 32 [PMID: 24900670] | Mayzent®|
|CAS Registry No.||1230487-00-9 (source: WHO INN record)|
|GtoPdb PubChem SID||318164808|
|Search Google for chemical match using the InChIKey||KIHYPELVXPAIDH-HNSNBQBZSA-N|
|Search Google for chemicals with the same backbone||KIHYPELVXPAIDH|
|Search PubMed clinical trials||siponimod|
|Search PubMed titles||siponimod|
|Search PubMed titles/abstracts||siponimod|
|Search UniChem for chemical match using the InChIKey||KIHYPELVXPAIDH-HNSNBQBZSA-N|
|Search UniChem for chemicals with the same backbone||KIHYPELVXPAIDH|