illudalic acid [Ligand Id: 8770] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL506661 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dual specificity protein phosphatase 22 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3924] [UniProtKB: Q9NRW4] | ||||||||
| ChEMBL | Inhibition of LMWPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452] | ||||||||
| ChEMBL | Inhibition of VHR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| RTP Type C/Receptor-type tyrosine-protein phosphatase C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575] | ||||||||
| ChEMBL | Inhibition of CD45 (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 5 | pIC50 | 10000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469] | ||||||||
| ChEMBL | Inhibition of PTPep (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| RTP Type F/Receptor-type tyrosine-protein phosphatase F in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3521] [GtoPdb: 1855] [UniProtKB: P10586] | ||||||||
| ChEMBL | Binding affinity to wildtype LAR catalytic domain D1 (unknown origin) assessed as inhibition constant by Michaelis-Menten analysis | B | 5.05 | pKi | 9000 | nM | Ki | Bioorg Med Chem Lett (2024) 104: 129740-129740 [PMID:38599294] |
| ChEMBL | Inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| ChEMBL | Inhibition of human recombinant LAR | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2008) 16: 7399-7409 [PMID:18579388] |
| GtoPdb | Measured utilising purified recombinant LAR catalytic domain. | - | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2008) 16: 7399-409 [PMID:18579388] |
| ChEMBL | Covalent inhibition of wildtype LAR catalytic domain D1 (unknown origin) | B | 7.18 | pIC50 | 66 | nM | IC50 | Bioorg Med Chem Lett (2024) 104: 129740-129740 [PMID:38599294] |
| RTP Type M/Receptor-type tyrosine-protein phosphatase mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4661] [GtoPdb: 1860] [UniProtKB: P28827] | ||||||||
| ChEMBL | Inhibition of PTPmu (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4.8 | pIC50 | 16000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| protein tyrosine phosphatase non-receptor type 11/Tyrosine-protein phosphatase non-receptor type 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] | ||||||||
| ChEMBL | Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4.54 | pIC50 | 29000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| protein tyrosine phosphatase non-receptor type 2/Tyrosine-protein phosphatase non-receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706] | ||||||||
| ChEMBL | Inhibition of TCPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| Tyrosine-protein phosphatase non-receptor type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2219] [UniProtKB: P35236] | ||||||||
| ChEMBL | Inhibition of HePTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
