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RTP Type F

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Target not currently curated in GtoImmuPdb

Target id: 1855

Nomenclature: RTP Type F

Family: Receptor tyrosine phosphatase (RTP) family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1907 1p34.2 PTPRF protein tyrosine phosphatase receptor type F
Mouse 1 1898 4 D2.1 Ptprf protein tyrosine phosphatase receptor type F
Rat 1 1898 5q36 Ptprf protein tyrosine phosphatase, receptor type, F
Previous and Unofficial Names Click here for help
LARFN5C | leukocyte antigen-related (LAR) PTP receptor | protein tyrosine phosphatase, receptor type, F | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type F
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Putative endogenous ligands
netrin-G3 ligand (LRRC4B, Q9NT99)  [1]

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
illudalic acid Small molecule or natural product Hs Inhibition 5.9 pIC50 2
pIC50 5.9 (IC50 1.3x10-6 M) [2]
Description: Measured utilising purified recombinant LAR catalytic domain.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


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1. Kwon SK, Woo J, Kim SY, Kim H, Kim E. (2010) Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. J Biol Chem, 285 (18): 13966-78. [PMID:20139422]

2. Ling Q, Huang Y, Zhou Y, Cai Z, Xiong B, Zhang Y, Ma L, Wang X, Li X, Li J et al.. (2008) Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg Med Chem, 16 (15): 7399-409. [PMID:18579388]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type F. Last modified on 15/09/2015. Accessed on 17/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,