Synonyms: compound 19f [PMID: 7830278] | OPC-6535 | OPC6535
Compound class:
Synthetic organic
Comment: Tetomilast is a PDE4 inhibitor. Inhibition of PDE4 blocks the oxidative burst in human neutrophils, which is a major mediator of tissue injury in inflammatory diseases. Tetomilast (OPC-6535) was originally identified as an inhibitor of superoxide production by human neutrophils [1]. The clinical potential of PDE4 inhibition in inflammatory bowel disease was reviewed by Salari and Abdollahiin 2012 [2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid |
International Nonproprietary Names | |
INN number | INN |
8430 | tetomilast |
Synonyms |
compound 19f [PMID: 7830278] | OPC-6535 | OPC6535 |
Database Links | |
CAS Registry No. | 145739-56-6 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL332750 |
DrugBank Ligand | DB05298 |
GtoPdb PubChem SID | 363894171 |
PubChem CID | 3025803 |
Search Google for chemical match using the InChIKey | XDBHURGONHZNJF-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | XDBHURGONHZNJF |
Search PubMed clinical trials | tetomilast |
Search PubMed titles | tetomilast |
Search PubMed titles/abstracts | tetomilast |
UniChem Compound Search for chemical match using the InChIKey | XDBHURGONHZNJF-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | XDBHURGONHZNJF-UHFFFAOYSA-N |