L-aspartic acid [Ligand Id: 3309] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL274323 (Aspartate, Aspartic acid, Aspartic acid,l, Aspartic acid, l-, Deamidated asparagine, FEMA NO. 3656, L-aspartic acid, NSC-3973)
  • Dihydrodipicolinate synthase in Escherichia coli K-12 [ChEMBL: CHEMBL4083] [UniProtKB: P0A6L2]
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  • Excitatory amino acid transporter 1 in Human [ChEMBL: CHEMBL3085] [GtoPdb: 868] [UniProtKB: P43003]
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  • Excitatory amino acid transporter 2 in Human [ChEMBL: CHEMBL4973] [GtoPdb: 869] [UniProtKB: P43004]
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  • Excitatory amino acid transporter 3 in Human [ChEMBL: CHEMBL2721] [GtoPdb: 870] [UniProtKB: P43005]
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  • Excitatory amino acid transporter 4 in Rat [ChEMBL: CHEMBL3700] [GtoPdb: 871] [UniProtKB: O35921]
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  • Glutamate transporter homolog in Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 /NBRC 100139 / OT-3) [ChEMBL: CHEMBL4296295] [UniProtKB: O59010]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dihydrodipicolinate synthase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4083] [UniProtKB: P0A6L2]
ChEMBL Reversible inhibition of Escherichia coli dihydrodipicolinate synthase using ASA as substrate B 4.05 pKi 90000 nM Ki MedChemComm (2019) 10: 1581-1588
Excitatory amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3085] [GtoPdb: 868] [UniProtKB: P43003]
ChEMBL Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method B 5.03 pIC50 9332.54 nM IC50 J Med Chem (2018) 61: 7741-7753 [PMID:30011368]
ChEMBL Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method B 5.03 pIC50 9300 nM IC50 J Med Chem (2018) 61: 7741-7753 [PMID:30011368]
Excitatory amino acid transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4973] [GtoPdb: 869] [UniProtKB: P43004]
ChEMBL Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method B 4.48 pIC50 33113.11 nM IC50 J Med Chem (2018) 61: 7741-7753 [PMID:30011368]
ChEMBL Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method B 4.49 pIC50 32000 nM IC50 J Med Chem (2018) 61: 7741-7753 [PMID:30011368]
Excitatory amino acid transporter 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2721] [GtoPdb: 870] [UniProtKB: P43005]
ChEMBL Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method B 4.7 pIC50 20000 nM IC50 J Med Chem (2018) 61: 7741-7753 [PMID:30011368]
ChEMBL Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method B 4.71 pIC50 19498.45 nM IC50 J Med Chem (2018) 61: 7741-7753 [PMID:30011368]
Excitatory amino acid transporter 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3700] [GtoPdb: 871] [UniProtKB: O35921]
ChEMBL Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method B 4.96 pIC50 11000 nM IC50 J Med Chem (2018) 61: 7741-7753 [PMID:30011368]
ChEMBL Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method B 4.96 pIC50 10964.78 nM IC50 J Med Chem (2018) 61: 7741-7753 [PMID:30011368]
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL Displacement of [3H]CPP from N-methyl-D-aspartate glutamate receptor in rat brain membrane B 5 pIC50 10000 nM IC50 J. Med. Chem. (1992) 35: 1345-1370 [PMID:1533422]
ChEMBL Compound was evaluated for the inhibition of [3H]-CGS-19,755 binding at N-methyl-D-aspartate glutamate receptor B 5.79 pIC50 1638 nM IC50 J. Med. Chem. (1992) 35: 4608-4612 [PMID:1361579]
Glutamate transporter homolog in Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 /NBRC 100139 / OT-3) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296295] [UniProtKB: O59010]
ChEMBL Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter L130W mutant fluorescence-based assay in presence of NaCl B 9 pKd 1 nM Kd Nature (2007) 445: 387-393 [PMID:17230192]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]