lorcaserin   Click here for help

GtoPdb Ligand ID: 2941

Synonyms: APD-356 | Belviq®
Approved drug
lorcaserin is an approved drug (FDA (2012))
Compound class: Synthetic organic
Comment: Lorcaserin is a selective, orally available and CNS active serotonin 2C receptor agonist that modulates appetite [2-3,5-6]. Cardiovascular safety in obese/overweight patients was reported by Bohula et al. (2018) [1].
Clinical formulations contain lorcaserin hydrochloride (PubChem CID 11673085).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 12.03
Molecular weight 195.08
XLogP 2.45
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES Clc1ccc2c(c1)C(C)CNCC2
Isomeric SMILES Clc1ccc2c(c1)[C@@H](C)CNCC2
InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
InChI Key XTTZERNUQAFMOF-QMMMGPOBSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2012))
Withdrawn drug? Yes
IUPAC Name Click here for help
(1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
International Nonproprietary Names Click here for help
INN number INN
8765 lorcaserin
Synonyms Click here for help
APD-356 | Belviq®
Database Links Click here for help
CAS Registry No. 616202-92-7 (source: Scifinder)
ChEMBL Ligand CHEMBL360328
DrugBank Ligand DB04871
DrugCentral Ligand 4374
GtoPdb PubChem SID 135650530
PubChem CID 11658860
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Wikipedia Lorcaserin