lorcaserin   Click here for help

GtoPdb Ligand ID: 2941

Synonyms: APD-356 | Belviq®
Approved drug PDB Ligand
lorcaserin is an approved drug (FDA (2012))
Compound class: Synthetic organic
Comment: Lorcaserin is a selective, orally available and CNS active serotonin 2C receptor agonist that modulates appetite [2-3,5-6]. Cardiovascular safety in obese/overweight patients was reported by Bohula et al. (2018) [1].
Clinical formulations contain lorcaserin hydrochloride (PubChem CID 11673085).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 12.03
Molecular weight 195.08
XLogP 2.45
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc2c(c1)C(C)CNCC2
Isomeric SMILES Clc1ccc2c(c1)[C@@H](C)CNCC2
InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2012))
Withdrawn drug? Yes
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
8765 lorcaserin
Synonyms Click here for help
APD-356 | Belviq®
Database Links Click here for help
Specialist databases
GPCRdb Ligand lorcaserin
Other databases
CAS Registry No. 616202-92-7 (source: Scifinder)
ChEMBL Ligand CHEMBL360328
DrugBank Ligand DB04871
DrugCentral Ligand 4374
GtoPdb PubChem SID 135650530
PubChem CID 11658860
RCSB PDB Ligand T4U, T4U
Search Google for chemical match using the InChIKey XTTZERNUQAFMOF-QMMMGPOBSA-N
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Search PubMed clinical trials lorcaserin
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UniChem Compound Search for chemical match using the InChIKey XTTZERNUQAFMOF-QMMMGPOBSA-N
UniChem Connectivity Search for chemical match using the InChIKey XTTZERNUQAFMOF-QMMMGPOBSA-N
Wikipedia Lorcaserin