ChEMBL ligand: CHEMBL685 (Chlorfenson, Emverm, K-6451, Mebendazol, Mebendazole, Mebendazole polymorph c, Mebendazolum, Mebenvet, NSC-184849, NSC-5618, Orthotran, Ovex, Ovitelmin, Ovochlor, Pantelmin, R 17,635, R-17635, Telmin, Telmintic, Vermicidin, Vermox, Zhihuanqing)
Calmodulin-domain protein kinase 1 in Toxoplasma gondii [ChEMBL: CHEMBL1781862] [UniProtKB: Q9BJF5] There should be some charts here, you may need to enable JavaScript!
Methionine aminopeptidase in Escherichia coli [ChEMBL: CHEMBL3423] [UniProtKB: P0AE18] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Calmodulin-domain protein kinase 1 in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781862] [UniProtKB: Q9BJF5]
ChEMBL	Inhibition of Toxoplasma gondii CDPK1	B	6.17	pIC50	670	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5264-5267 [PMID:22795629]
Methionine aminopeptidase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3423] [UniProtKB: P0AE18]
ChEMBL	Inhibition of Co2+ loaded MetAP expressed in Escherichia coli	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 511-522 [PMID:16420038]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Inhibition of human ABL by radiometric assay	B	5.34	pKi	4600	nM	Ki	J Med Chem (2012) 55: 2803-2810 [PMID:22369268]
ChEMBL	Inhibition of human ABL	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5264-5267 [PMID:22795629]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of human SRC by radiometric assay	B	5	pKi	>10000	nM	Ki	J Med Chem (2012) 55: 2803-2810 [PMID:22369268]
ChEMBL	Inhibition of human SRC	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5264-5267 [PMID:22795629]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibition of VEGFR2-mediated angiogenesis in human HUVEC cells after 24 hrs by inverted photomicroscopic analysis	B	5.06	pIC50	8800	nM	IC50	J Med Chem (2012) 55: 6832-6848 [PMID:22780961]
ChEMBL	Inhibition of human VEGFR2 (789 to 1356 residues) assessed as reduction in autophosphorylation at Y1175 residues using poly (Glu4Tyr1) peptide and ATP as substrate incubated for 60 mins by ADP-Glo Kinase Assay	B	5.37	pIC50	4300	nM	IC50	Eur J Med Chem (2021) 215: 113268-113268 [PMID:33636537]
ChEMBL	Inhibition of VEGFR2 after 60 mins by electrophoretic mobility shift assay	B	5.44	pIC50	3600	nM	IC50	J Med Chem (2012) 55: 6832-6848 [PMID:22780961]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]