apicidin [Ligand Id: 7495] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL430060 (Acipidin) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726] | ||||||||
| ChEMBL | Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay | B | 6.7 | pIC50 | 200 | nM | IC50 | J Biol Chem (2007) 282: 28408-28418 [PMID:17675290] |
| ChEMBL | Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay | B | 6.82 | pIC50 | 150 | nM | IC50 | J Biol Chem (2007) 282: 28408-28418 [PMID:17675290] |
| Histone deacetylase in Cryptosporidium parvum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4740] [UniProtKB: Q9GU59] | ||||||||
| ChEMBL | Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa | B | 8.1 | pKi | 8 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 113-117 [PMID:11206439] |
| ChEMBL | Tested for Histone deacetylase enzyme inhibition assay using Eimeria tenella extract | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2000) 43: 4919-4922 [PMID:11124001] |
| Histone deacetylase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2009) 52: 2185-2187 [PMID:19317450] |
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of human HDAC1 | B | 10.4 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| GtoPdb | - | - | 10.4 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of HDAC1 (mean IC50) | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5948-5952 [PMID:16987657] |
| ChEMBL | Inhibition of HDAC1 | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2008) 51: 2350-2353 [PMID:18370373] |
| ChEMBL | Inhibition of human recombinant C-terminally flag tagged HDAC1 | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5528-5532 [PMID:18809328] |
| ChEMBL | Inhibition of C-terminal FLAG tagged HDAC1 | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3081-3084 [PMID:19410459] |
| ChEMBL | Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3651-3656 [PMID:19457659] |
| ChEMBL | Inhibition of HDAC1 in HEK293 cells | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 7.66 | pIC50 | 22 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
| ChEMBL | Inhibition of human recombinant HDAC1 after 30 mins by fluorimetric assay | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2009) 52: 7836-7846 [PMID:19705846] |
| ChEMBL | Inhibition of HDAC1 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry | B | 7.66 | pIC50 | 22 | nM | IC50 | ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958] |
| ChEMBL | Inhibition of HDAC1 | B | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2549-2554 [PMID:18381239] |
| ChEMBL | Inhibition of human recombinant HDAC1 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 7.96 | pIC50 | 11 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
| ChEMBL | Inhibition of HDAC1 | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| GtoPdb | - | - | 9.92 | pKi | 0.12 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC2 | B | 9.92 | pKi | 0.12 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 7.46 | pIC50 | 35 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) | B | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
| ChEMBL | Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 7.47 | pIC50 | 34 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
| ChEMBL | Inhibition of HDAC2 | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
| GtoPdb | - | - | 6.92 | pEC50 | 120 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| ChEMBL | Inhibition of human HDAC3 | B | 9.59 | pKi | 0.26 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| GtoPdb | - | - | 9.59 | pKi | 0.26 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human recombinant HDAC3 after 30 mins by fluorimetric assay | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2009) 52: 7836-7846 [PMID:19705846] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) | B | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
| ChEMBL | Inhibition of HDAC3 in HEK293 cells | B | 8.01 | pIC50 | 9.7 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
| ChEMBL | Inhibition of flag-tagged HDAC3 | B | 8.6 | pIC50 | 2.5 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988] |
| ChEMBL | Inhibition of HDAC3 | B | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
| GtoPdb | - | - | 7.37 | pEC50 | 43 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
| GtoPdb | - | - | 7.52 | pEC50 | 30 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
| histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] | ||||||||
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay | B | 8.82 | pKi | 1.5 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| GtoPdb | - | - | 9.59 | pKi | 0.26 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of HDAC3-NCoR2 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry | B | 7.54 | pIC50 | 29 | nM | IC50 | ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958] |
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay | B | 7.8 | pIC50 | 15.8 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| ChEMBL | Inhibition of human recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 7.89 | pIC50 | 13 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
| GtoPdb | - | - | 7.37 | pEC50 | 43 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
| GtoPdb | - | - | 7.52 | pEC50 | 30 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
| histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] | ||||||||
| ChEMBL | Inhibition of wild type HDAC4 expressed in Escherichia coli | B | 5.06 | pIC50 | 8700 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
| ChEMBL | Inhibition of HDAC4 H976Y mutant expressed in Escherichia coli | B | 5.44 | pIC50 | 3600 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
| ChEMBL | Inhibition of flag-tagged HDAC4 by pull-down assay | B | 8.62 | pIC50 | 2.4 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988] |
| ChEMBL | Inhibition of flag-tagged HDAC4 by Biomol assay | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988] |
| ChEMBL | Inhibition of flag-tagged HDAC4 | B | 9 | pIC50 | 1 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay | B | 6.91 | pKi | 123.4 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| ChEMBL | Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958] |
| ChEMBL | Inhibition of HDAC6 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
| ChEMBL | Inhibition of human recombinant HDAC6 after 30 mins by fluorimetric assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2009) 52: 7836-7846 [PMID:19705846] |
| ChEMBL | Inhibition of human recombinant HDAC6 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
| ChEMBL | Inhibition of HDAC6 | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
| ChEMBL | Inhibition of HDAC6 in HEK293 cells | B | 5.37 | pIC50 | 4300 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay | B | 6.18 | pIC50 | 665.1 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| ChEMBL | Activity of human HDAC8 | B | 7.31 | pKi | 49 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| GtoPdb | - | - | 7.31 | pKi | 49 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human recombinant HDAC8 after 30 mins by fluorimetric assay | B | 6.12 | pIC50 | 760 | nM | IC50 | J Med Chem (2009) 52: 7836-7846 [PMID:19705846] |
| ChEMBL | Inhibition of HDAC8 (unknown origin) | B | 6.12 | pIC50 | 760 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
| ChEMBL | Inhibition of HDAC8 in human HeLa cells nuclear extract using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by spectrophotometry | B | 6.12 | pIC50 | 755 | nM | IC50 | ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958] |
| ChEMBL | Inhibition of human recombinant HDAC8 using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 6.12 | pIC50 | 750 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
| ChEMBL | Inhibition of HDAC8 | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
| GtoPdb | - | - | 6.24 | pEC50 | 575 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
| Histone deacetylase-like amidohydrolase in Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6017] [UniProtKB: Q70I53] | ||||||||
| ChEMBL | Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropy | B | 5.04 | pKi | 9200 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 3651-3656 [PMID:19457659] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 48 hrs by light microscopic analysis | F | 6.7 | pIC50 | 200 | nM | IC50 | J Nat Prod (2013) 76: 2136-2140 [PMID:24195442] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake | F | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2009) 52: 2185-2187 [PMID:19317450] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
