ChEMBL ligand: CHEMBL437 (NSC-31812, NSC-683531, Sulfathiazol, Sulfathiazole, Sulfathiazole (triple sulfa), Sulfatiazol, Sulphathiazole, Thiazamide, Triple sulfa (sulfathiazole))
Dihydropteroate synthase in Escherichia coli [ChEMBL: CHEMBL4032] [UniProtKB: P0AC13] There should be some charts here, you may need to enable JavaScript!
ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] ETA receptor/Endothelin receptor ET-A in Rat [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 6/Protein arginine N-methyltransferase 6 in Human [ChEMBL: CHEMBL1275221] [GtoPdb: 1257] [UniProtKB: Q96LA8] There should be some charts here, you may need to enable JavaScript!
Transcriptional activator protein lasR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL1075207] [UniProtKB: P25084] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Dihydropteroate synthase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4032] [UniProtKB: P0AC13]
ChEMBL	In vitro inhibition of dihydropteroate synthase from Escherichia coli.	B	5.6	pIC50	2500	nM	IC50	J Med Chem (1985) 28: 1870-1874 [PMID:3906132]
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL	Inhibitory concentration against Endothelin A receptor	B	4.16	pIC50	69000	nM	IC50	J Med Chem (2004) 47: 1303-1314 [PMID:14998318]
ETA receptor/Endothelin receptor ET-A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684]
ChEMBL	Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.	B	4.16	pIC50	69000	nM	IC50	J Med Chem (1995) 38: 1344-1354 [PMID:7731020]
protein arginine methyltransferase 6/Protein arginine N-methyltransferase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1275221] [GtoPdb: 1257] [UniProtKB: Q96LA8]
ChEMBL	Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay	B	3.37	pIC50	430000	nM	IC50	J Med Chem (2016) 59: 1176-1183 [PMID:26824386]
Transcriptional activator protein lasR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075207] [UniProtKB: P25084]
ChEMBL	Inhibition of LasR in Pseudomonas aeruginosa harboring GFP-fused quorum sensing lasB measured every 15 mins up to 12 hrs by GFP reporter gene assay	B	5.05	pIC50	9000	nM	IC50	J Med Chem (2018) 61: 10385-10402 [PMID:29999316]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]