cephalothin [Ligand Id: 8798] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL617 (Seffin, Cefalotin, Cephalothin)
  • Organic anion transporter 4/Solute carrier family 22 member 11 in Human [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0]
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
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  • Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
  • Organic anion transporter 3/Solute carrier family 22 member 8 in Rat [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Organic anion transporter 4/Solute carrier family 22 member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0]
ChEMBL TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells F 6.7 pKi 200 nM Ki Eur. J. Pharmacol. (2002) 438: 137-142 [PMID:11909604]
GtoPdb - - 6.7 pKi 200 nM Ki Eur J Pharmacol (2002) 438: 137-42 [PMID:11909604]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells F 6.66 pKi 220 nM Ki Eur. J. Pharmacol. (2002) 438: 137-142 [PMID:11909604]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells F 7.4 pKi 40 nM Ki Eur. J. Pharmacol. (2002) 438: 137-142 [PMID:11909604]
GtoPdb - - 7.59 pIC50 26 nM IC50 Eur J Pharmacol (2002) 438: 137-42 [PMID:11909604]
Organic anion transporter 3/Solute carrier family 22 member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
ChEMBL TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells F 4.32 pKi 48000 nM Ki Life Sci. (2002) 70: 1861-1874 [PMID:12005172]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]