Organic anion transporter 3 | Organic anion transporters (OATs) | IUPHAR/BPS Guide to PHARMACOLOGY

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Organic anion transporter 3

Target not currently curated in GtoImmuPdb

Target id: 1027

Nomenclature: Organic anion transporter 3

Abbreviated Name: OAT3

Systematic Nomenclature: SLC22A8

Family: Organic anion transporters (OATs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 11 542 11q12.3 SLC22A8 solute carrier family 22 member 8
Mouse 11 537 19 5.44 cM Slc22a8 solute carrier family 22 (organic anion transporter), member 8
Rat 11 536 1q43 Slc22a8 solute carrier family 22 member 8
Previous and Unofficial Names
OCT3 | organic anion transporter 3 | solute carrier family 22 member 8 | solute carrier family 22 (organic anion transporter), member 8 | solute carrier family 22 (organic anion transporter)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC22A8 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
cimetidine Hs - 2
ochratoxin A Hs - 2
uric acid Hs - - 3
estrone-3-sulphate Hs - 2
aminohippuric acid Hs - 2
tenofovir Hs - - 1

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cephalothin Hs Inhibition 7.6 pIC50 4
pIC50 7.6 (IC50 2.6x10-8 M) [4]


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1. Fernandez-Fernandez B, Montoya-Ferrer A, Sanz AB, Sanchez-Niño MD, Izquierdo MC, Poveda J, Sainz-Prestel V, Ortiz-Martin N, Parra-Rodriguez A, Selgas R et al.. (2011) Tenofovir nephrotoxicity: 2011 update. AIDS Res Treat, 2011: 354908. [PMID:21716719]

2. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H. (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem., 274 (19): 13675-80. [PMID:10224140]

3. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr. Opin. Nephrol. Hypertens., 27 (4): 305-313. [PMID:29847376]

4. Takeda M, Babu E, Narikawa S, Endou H. (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur. J. Pharmacol., 438 (3): 137-42. [PMID:11909604]


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