aminohippuric acid   Click here for help

GtoPdb Ligand ID: 4810

Abbreviated name: PAH
Synonyms: Aminohippurate Sodium® | p-aminohippurate | p-aminohippuric acid | PAH
Approved drug PDB Ligand
aminohippuric acid is an approved drug (FDA (1944))
Compound class: Metabolite
Comment: Aminohippuric acid is an amide derivative of the amino acid glycine, not naturally found in humans.
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 92.42
Molecular weight 194.07
XLogP -2.17
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES O=C(c1ccc(cc1)N)NCC(=O)O
Isomeric SMILES O=C(c1ccc(cc1)N)NCC(=O)O
InChI InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)
InChI Key HSMNQINEKMPTIC-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Metabolite
Approved drug? Yes (FDA (1944))
IUPAC Name Click here for help
2-[(4-aminophenyl)formamido]acetic acid
Synonyms Click here for help
Aminohippurate Sodium® | p-aminohippurate | p-aminohippuric acid | PAH
Database Links Click here for help
CAS Registry No. 94-16-6
ChEMBL Ligand CHEMBL463
DrugBank Ligand DB00345
DrugCentral Ligand 165
GtoPdb PubChem SID 178101512
PubChem CID 2148
RCSB PDB Ligand ZWD
Search Google for chemical match using the InChIKey HSMNQINEKMPTIC-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HSMNQINEKMPTIC
UniChem Compound Search for chemical match using the InChIKey HSMNQINEKMPTIC-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey HSMNQINEKMPTIC-UHFFFAOYSA-N
Wikipedia Aminohippuric_acid