Organic anion transporters (OATs) are non-selective transporters prominent in the kidney, placenta and blood-brain barrier.

* Key recommended reading is highlighted with an asterisk

* Burckhardt G, Burckhardt BC. (2011) In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy. Handb Exp Pharmacol, (201): 29-104. [PMID:21103968]

* Koepsell H. (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med, 34 (2-3): 413-35. [PMID:23506881]

* Nigam SK. (2018) The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease. Annu Rev Pharmacol Toxicol, 58: 663-687. [PMID:29309257]

* Shen H, Lai Y, Rodrigues AD. (2017) Organic Anion Transporter 2: An Enigmatic Human Solute Carrier. Drug Metab Dispos, 45 (2): 228-236. [PMID:27872146]

* Yee SW, Giacomini KM. (2021) Emerging Roles of the Human Solute Carrier 22 Family. Drug Metab Dispos, 50 (9): 1193-210 [Epub ahead of print]. [PMID:34921098]

* Yin J, Wang J. (2016) Renal drug transporters and their significance in drug-drug interactions. Acta Pharm Sin B, 6 (5): 363-373. [PMID:27709005]

1. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H. (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem, 275 (6): 4507-12. [PMID:10660625]

2. Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H. (2003) Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int, 63 (1): 143-55. [PMID:12472777]

3. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H. (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem, 274 (19): 13675-80. [PMID:10224140]

4. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens, 27 (4): 305-313. [PMID:29847376]